Leland Stanford Junior University

Gilead Sciences, Inc.

Elena Bekerman

Winston C Tse

Tomas Cihlar

Shirit Einav

Steven De Jonghe

Anna Chiu

Gregory Neveu

Dana J Levine

Stephen R Yant

Wade S Blair

Jim X Zheng

Piet Herdewyn

The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.

Capsid inhibitors for the prevention of HIV

The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.

GAK modulators as antivirals

Growing community of inventors

Castro Valley, CA, United States of America

Elena Bekerman