Apotex Pharmachem Inc.

Alphora Research Inc.

Eon Labs, Inc.

Elena Bejan

Stephen E Horne

Svetoslav S Bratovanov

Boris Gorin

Zhi-Xian Wang

Gamini Weeratunga

Bhaskar Reddy Guntoori

Jan Oudenes

David A Stradiotto

Bruce Goodbrand

Mohamed Ibrahim Zaki

Graham McGowan

Walter Giust

Abbulu Kante

Fabio Souza

Disclosed is a process for preparing a treprostinil salt. The process involves the step of dissolving treprostinil in a water-miscible organic solvent to form a treprostinil solution. The treprostinil solution is reacted with an aqueous basic solution containing an alkali metal cation to form treprostinil salt. Allowing crystallization of the treprostinil salt to take place, and then collecting the treprostinil salt formed.

Process for treprostinil salt preparation

A para-methoxy protected benzaldehyde useful in preparation of treprostinil, and of formula: (Formula (1)) is prepared by subjecting to Claisen re-arrangement a substituted benzaldehyde of formula (1a): (Formula (Ia)) to form the m-hydroxy-substituted benzaldehyde of formula (1b): (Formula (Ib)) and then reacting compound (1b) with a p-methoxybenzyl (PMB) compound to form a PMB-substituted benzaldehyde of formula (1). 

Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation

An industrially acceptable process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine from a cis/trans mixture of isomers. Treatment of the mixture with an organic sulfonic acid generates a less soluble acid addition salt that is enriched in the cis-isomer. Recrystallization or pulping using various organic solvents allows for enrichment of the cis-isomer by filtration. These new sulfonic acid salts of the cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3&#x2032;)quiniclidine prepared according to the present invention could be further converted into the hydrochloride salt by any known procedures such as treatment with a base and then hydrochloric acid salt formation or exchange of the sulfonic acid salt with hydrochloric acid.

Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine hydrochloride

An industrially acceptable process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3')quiniclidine. The cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3&#x2032;)quiniclidine is known generally as Cevimeline.

Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3')quiniclidine

A process for the preparation and purification of Eplerenone is described wherein hydroxylated impurities are removed using a novel derivatization procedure.

Process for the preparation and purification of eplerenone

A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L-alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutically acceptable salts thereof, comprising the steps of:   

Process for the preparation of polypeptide 1

Growing community of inventors

Brantford, Canada

Elena Bejan