Uchicago Argonne, LLC

Elena A Rozhkova

Tijana Rajh

Petr Nikitin

Nada M Dimitrijevic

Valentine Novosad

Maxim Nikitin

Elena Shevchenko

Richard D Schaller

Peng Wang

Harry C Fry

Tamara Koritarov

Bartosz Gryzbowski

Shankar G Balasubramanian

Products and methods for redirecting the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious hypoxia conditions toward the reduction of the precursor salt and the biosynthesis of biologically compatible, antioxidant noble metal nanoparticles and the simultaneous restoring of the tissue redox state are provided. The products and methods have application in the treatment of hypoxia and hypoxia-related diseases and disorders. Such products and methods are also useful in organ transplantation and recovery, in screening of anti-hypoxia agents, and in detecting elevated levels of the reducing equivalents of the redox state, for example, NADH, NADPH, GSH, and TrxSH, in cells, tissues, or organs.

Products and methods for organ protection with noble nanoparticles

A significant enhancement of detection capabilities of the room temperature MPQ is seen using optical lithography-defined, ferromagnetic iron-nickel alloy microdisks. Irreversible transitions between strongly non-collinear (vortex) and a collinear single domain states, driven by an ac magnetic field, translate into a nonlinear magnetic response that enables ultrasensitive detection of material at relatively small magnetic fields.

Ferromagnetic particles as ultra-sensitive non-linear response labels for magnetic particles imaging (MPI) and sensing applications

A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.

Metal oxide nanoparticle for cell lysis

Aspects of the disclosure relate to an efficient entirely man-made nanobio hybrid fabricated through cell-free expression of transmembrane proton pump followed by assembly of the synthetic protein architecture with semiconductor nanoparticles for photocatalytic Hevolution. The system produces Hat a turnover rate of 240 &#x3bc;mol of H(&#x3bc;mol protein)hunder green and 17.74 mmol of H(&#x3bc;mol protein)hunder white light at ambient conditions, in water at neutral pH with methanol as a sacrificial electron donor. Robsutness and flexibility of this approach allows for systemic manipulation at nanoparticle-bio interface toward directed evolution of energy materials and devices.

Semiconductor-metal nanoparticle hybrids with natural and artificial proton pump for hydrogen production

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Lemont, IL, United States of America

Elena A Rozhkova