University of California

Elena A Dubikovskaya

Carolyn Ruth Bertozzi

Christopher J Chang

Genevieve C Van De Bittner

Andreas Stahl

Amy Helene Fluitt

Allison Cohen

The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.

Luciferin derivatives from bicyclic reactants and aminothiol derivatives and methods of use thereof

The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.

Compositions and methods for in vivo imaging

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Lausanne, Switzerland

Elena A Dubikovskaya