National Institutes of Health, a Component of the US Dept. of Health & Human Services

Loyola University of Chicago

Elena A Cherkasova

Richard W Childs

Michael I Nishimura

Disclosed herein are T cell receptors (TCRs) capable of binding an antigen expressed by renal cell carcinoma cells. In some examples, the TCRs include an &#x3b1; chain (such as SEQ ID NO: 2) and a &#x3b2; chain (such as SEQ ID NO: 3). Also disclosed herein are vectors including nucleic acids encoding the disclosed TCR &#x3b1; and/or &#x3b2; chains. Further disclosed are modified T cells expressing the TCRs. In some examples, the modified T cells are prepared by transducing T cells with a vector including nucleic acids encoding the TCR &#x3b1; chain and the TCR &#x3b2; chain. In some embodiments, methods include treating a subject with RCC, by obtaining a population of T cells, transducing the population of T cells with a vector including a nucleic acids encoding the TCR &#x3b1; chain and the TCR &#x3b2; chain, and administering a composition comprising the modified T cells to the subject.

Growing community of inventors

Rockville, MD, United States of America

Elena A Cherkasova