Egis Gyogyszergyar

Elemer Jakflavi

Gabor Blasko

Ivan Beck

Judit Kun

Agnes Kovacs Nee Palotai

Geza Schneider

Andras Dietz

Gabriella Rmos Nee Lassu

Ilma Dinnyes Nee Nagy

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). ##STR1## which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) ##STR2## in an inert solvent, in the presence of a catalyst, at a temperature of 50.degree. to 120.degree. C. under a pressure of 10.sup.5 to 10.sup.7 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). ##STR3##

Process for preparing 1-(2S)-3-mercapto-methyl-1-oxopropyl)-L-proline

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Budapest, Hungary

Elemer Jakflavi