Pharmacia & Upjohn Company

The Upjohn Co.

Other

Eldon George Nidy

Jackson B Hester, Jr

Salvatore Charles Perricone

Toni-Jo Poel

Robert C Kelly

Roy A Johnson

Harvey I Skulnick

Gabriel Kornis

Arnolds Steinhards, Deceased

Henry J Vostral

Salvatore Charges Perricone

This invention provides 7-deoxy-taxol analogs of Formula I: The compounds of Formula I (including II and III) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

Method of preparing a taxol derivative

Oxazolidinone antibacterial agents having a thiocarbonyl funtionality

Oxazolidinone antibacterial agents having a thiocarbonyl functionality

The present invention provides compounds of Formula 1

This invention provides 7-deoxy-.DELTA..sup.6,7 -taxol and 7-deoxy-.DELTA..sup.6,7 -taxol analogs of Formula I: ##STR1## The compounds of Formula I are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malignant melanoma as well as lung cancer, gastric cancer, colon cancer, head and neck cancer, and leukemia.

.DELTA..sup.6,7 -taxols antineoplatic use and pharmaceutical

Certain new 1-(substituted-hydrocarbyl)-di- and trihalopyrazoles have been synthesized. They possess herbicidal and plant growth regulatory activity. The hydrocarbyl group, i.e., alkylene or alkenylene group at the 1-nitrogen of the pyrazole nucleus has either a carboxyl group, an hydroxymethyl group, an hydroxymethyl lower-alkanoate group a carboxylic lower-alkyl ester group a cyano group or a carboxylic amide group. The new compounds are prepared and isolated by conventional chemical reactions and procedures. An improved reaction for making the new carboxylic acids is described. Weed control methods and compositions for herbicidal use are also described.

1-(Substituted-hydrocarbyl)-di- and trihalopyrazoles

Certain new 1-(substituted-hydrocarbyl)-di- and trihalopyrazoles have been synthesized. They possess herbicidal and plant growth regulatory activity. The hydrocarbyl group, i.e., alkylene or alkenylene group at the 1-nitrogen of the pyrazole nucleus has either a carboxyl group, an hydroxymethyl group, an hydroxymethyl lower-alkanoate group, a carboxylic lower-alkyl ester group, a cyano group, or a carboxylic amide group. The new compounds are prepared and isolated by conventional chemical reactions and procedures. An improved reaction for making the new carboxylic acids is described. Weed control methods and compositions for herbicidal use are also described.

Organic compounds and process

Growing community of inventors

Kalamazoo, MI, United States of America

Eldon George Nidy