Riker Laboratories Inc.

Minnesota Mining and Manufacturing Company

Elden H Banitt

William R Bronn

Roy L McQuinn

William E Coyne

James D Johnson

Certain 2,5-disubstituted N-(2-piperidylmethyl)benzamides, wherein one substituent is 2,2,2-trifluoroethyoxy, and pharmaceutically acceptable acid-addition salts thereof, are active as antiarrhythmic agents.

Antiarrhythmic substituted N-(2-piperidylmethyl)benzamides

Certain substituted cyclopentanone ethylene ketal compounds, and ketones and amides derived therefrom are useful synthetic intermediates for compounds of pharmaceutical interest. A synthetic process for using the intermediates is also described.

Cyclopentanone derivatives

Synthetic 5-hydroxy-N-(6-oxo-2-piperidylmethyl)-2-(2,2,2-trifluoroethoxy) benzamide. The compound 5-hydroxy-N-(6-oxo-2-piperidylmethyl)-2-(2,2,2-trifluoroethoxy) benzamide is a metabolite of the antiarrhythmic agent 2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide.

Metabolite

Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically acceptable salts, are active antiarrhythmic agents.

Ethoxyphenyl piperidines and uses thereof

A novel N-(2-piperidylmethyl)-2,2,2-trifluoroethoxy)benzamide and its pharmaceutically acceptable salts.

Phenolic derivative

Substituted 2-(trifluoroethoxy)benzamide, benzoic acid and benzoate compounds which are intermediates in the preparation of pharmaceutically active agents.

5-Benzyloxy or

Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a phenyl-substituted urea, and their pharmaceutically acceptable salts, are active anti-arrhythmic agents.

N-(1,1-dihydroperfluoroalkoxyphenyl)-N'-(pyridyl)-substituted ureas

Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the completely substituted nitrogen of a substituted benzamido group, and their pharmaceutically acceptable salts, are active antiarrhythmic agents.

Tertiary amide derivatives of pyrrolidine and piperidine

Derivatives of urea

Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a substituted benzamido group, and their pharmaceutically acceptable salts, are found to be active as antiarrhythmic agents.

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Woodbury, MN, United States of America

Elden H Banitt