Massachusetts Institute of Technology

Abiomed, Inc.

Harvard College

Innovational Holdings LLC

The Brigham and Women's Hospital, Inc.

Other

Conor Medsystems, Inc.

Biorest Ltd.

E.i. Dupont De Nemours and Company

The General Hospital Corporation

Children's Medical Center Corporation

Nof Corporation

Medinol Ltd.

Zuli Holdings Ltd.

W. L. Gore & Associates, Inc.

Elazer Reuven Edelman

Natalie Artzi

Sonya Sanat Bhavsar

John Francis Shanley, Iv

Neal L Eigler

Brian Yale Chang

Noam Josephy

Robert Samuel Langer

Yoram Richter

Gershon Golomb

Adam Groothuis

Haim D Danenberg

Adrian Ebner

Peter Markham

Kinam Park

Ahmad El Katerji

Steven F Keller

David H Adams

Qing Tan

Garret D Figuly

Pedro J Del Nido

Rinaldo Soria Schiffino

Surbhi Mahajan

David T Ting

Peter E Hammer

Alexander Ship

Christian Moyer

Steve Bollinger

Kumaran Kolandaivelu

Mark A Lovich

Yi Zhang

Yuji Yamamoto

Edith Mathiowitz

Hiroki Yoshioka

Larry Richard Brown

Robert D Rosenberg

Ken-ichiro Nakamoto

Michael Simons

Robert S Langer, Jr

Lyndon Fitzgerald Charles, Jr

James Conrad Squire

Peter Heicksen

Regina Kelmansky

Morris J Karnovsky

Marc Mier Cervantes

Christopher Payne

Jeffrey W Clark

Sophie-Charlotte Hofferberth

Laura Indolfi

Peter D Traylor

Michael Jordan Feldstein

Noam Joesphy

Cristina Rosa Annamaria Ferrone

Matteo Ligorio

James C Squire

Max Louis Olender

Tarek Michael Shazly

Helen Marie Nugent

Shimon Unterman

Núria Oliva Jorge

Matthew A Nugent

Jean-Luc DeKeyser

Michael Klagsburn

Campbell Rogers

Hyun Seok Song

Aruna Nathan

Campell Rogers

Paul Tierstein

Sara Elaine Strecker

Maria Carcole Solanes

Kay Dee Furman

Gerard J Desany

Heiko Methe

Brett Zani

Maria Carcolé Solanes

Sujata K Bhatia

Lambros Athanasiou

David Tseng

Abraham Tzafriri

Steven Keller

Ken-Ichiro Nakamoto

Theresa Holland

Steven M Alston

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

Cardiovascular assist system that quantifies heart function and facilitates heart recovery

The present embodiments relate to systems and methods for treating luminal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of luminal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

Systems and methods for treating luminal valves

A system for completing a medical image having at least one obscured region includes an input for receiving a first classification map generated using an acquired optical coherence tomography (OCT) image having at least one obscured region, the acquired OCT image acquired using an imaging system and a pre-processing module coupled to the input and configured to create an obscured region mask. The pre-processing module also generates a second classification map that has the at least one obscured region filled in. The system also includes a generative network coupled to the pre-processing module and configured to generate a synthetic OCT image based on the second classification map and a post-processing module coupled to the generative network. The post-processing module is configured to receive the synthetic OCT image and the acquired OCT image and to generate a completed image based on the synthetic OCT image and the acquired OCT image.

Systems and methods for utilizing synthetic medical images generated using a neural network

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Systems and methods for determining cardiac performance

A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed.

A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.

Geometrically-accommodating heart valve replacement device

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Systems and methods for determining cardiac output

Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 &#x3bc;m to about 1000 &#x3bc;m, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

Local drug delivery devices and methods for treating cancer

A method, including: obtaining, by a processor, imaging data from a vessel; detecting, using the processor, an inner wall of the vessel based on the imaging data; identifying, using the processor, a plurality of visible edge portions of an outer wall of the vessel based on the imaging data; fitting, using the processor, a continuous surface model to the plurality of identified visible edge portions of the outer wall; and detecting, using the processor, the outer wall of the vessel based on fitting the continuous surface model to the plurality of identified visible edge portions of the outer wall such that the imaging data has defined therein a wall area between the inner wall and the outer wall of the vessel.

Arterial wall characterization in optical coherence tomography imaging

Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.

Controllably degradable compositions and methods

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.

Growing community of inventors

Brookline, MA, United States of America

Elazer Reuven Edelman