Cornell University

Fred Hutchinson Cancer Center

Fred Hutchinson Cancer Research Center

Elaine Ostrander

Gustavo D Aguirre

Gregory M Acland

Orly Goldstein

Anna V Kukekova

Dayna Akey

Scott M Carlson

Leonid Kruglyak

Heidi G Parker

Lisa V Kim

Matthew Stephens

Tiffany B Malek

Nathan B Sutter

In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.

Methods and materials for canine breed identification

The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence or absence of a 7.8 kilobase deletion within chromosome 37 in which the CEA mutation is located. No deletion is indicative of a normal dog. A deletion on one allele of chromosome 37 is indicative of a dog that is heterozygous for the CEA mutation. A deletion in both alleles of chromosome 37 are indicative of a dog that is homozygous for the CEA mutation. Also provided is a kit for identifying a dog as normal, heterozygous for, or homozygous for the CEA mutation.

Diagnostic test for Collie Eye Anomaly

The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence or absence of a 7.8 kilobase deletion within chromosomein which the CEA mutation is located. No deletion is indicative of a normal dog. A deletion on one allele of chromosomeis indicative of a dog that is heterozygous for the CEA mutation. A deletion in both alleles of chromosomeare indicative of a dog that is homozygous for the CEA mutation. Also provided is a kit for identifying a dog as normal, heterozygous for, or homozygous for the CEA mutation.

Diagnostic test for collie eye anomaly

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Potomac, MD, United States of America

Elaine Ostrander