Bristol-myers Squibb Compnay

Genetic Systems Corporation

Elaine K Thomas

Allan Sachs Hoffman

John H Priest

Wesley Loren Cosand

Robert C Nowinski

Dennis E Schwartz

Larry H Gosting

Mary K Shriver

Janela McClure

Edna S Dickinson

Methods and composition for HIV diagnosis and treatment using monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, using the peptides or homologs thereof from that region, and using related nucleic acid segments. Exemplary neutralizing regions include selected portions of the env and gag genes from various HIV isolates. Monoclonal antibody secreting cell lines include HIV-gp110-1, -2, -3, -4, -5 and -6 (A.T.C.C. Accession Nos. HB9175, HB9176, HB9177, HV9405, HB9406 and HB9404, respectively) and HIV-p25-2, -3, -6 and -7 (A.T.C.C. Accession Nos. HB9407, HB9408, HB9409 and HB9410, respectively).

Monoclonal antibodies and peptides useful in treating and diagnosing HIV

Methods and compounds are disclosed for determining the presence, amount of, or association between substances of interest in samples suspected of containing same. The methods are based on the polymerization-induced separation of specifically-bound, reporter-labeled recognition reactants from free, reporter-labeled recognition reactants. The methods described are applicable to any substance for which suitable recognition reactants exist or can be made and are not limited by considerations such as chemical composition or molecular size.

Polymerization-induced separation assay using recognition pairs

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Seattle, WA, United States of America

Elaine K Thomas