James Black Foundation Limited

Elaine Anne Harper

Sarkis Barret Kalindjian

Nigel Paul Shankley

Ildiko Maria Buck

Iain Mair McDonald

Michael John Pether

Matthew John Tozer

Gillian Fairfull Watt

Caroline M Low

David John Dunstone

Ian Duncan Linney

Robert A Hull

Sonia Patricia Roberts

Paul Wright

Katherine Isobel Steel

James Black

Caroline Minli Rachel Low

Jonathan Michael Davies

Katherine Isobel Mary Steel

Martin Lyn Hudson

Tracey Cooke

Martin Keith Walker

Elliot James Lilley

David Andrew Sykes

Eric Peter Griffin

Laurence Wright

John David Gaffen

Robert Antony David Hull

Michael J Bodkin

Jeremy Gilbert Vinter

Atul Kotecha

Compounds of formula (I) (and pharmaceutically acceptable salts thereof) are histamine Hreceptor ligands. A in the formula represents (CH), m being from 1 to 3; B is (CH), n being from 1 to 3; x is from 0 to 2; Ris Cto Chydrocarbyl, in which up to 2 carbon atoms may be replaced by O, S or N; and up to 2 hydrogen atoms may be replaced by halogen; Ris H or Cto Chydrocarbyl, in which up to 3 carbon atoms may be replaced by O, S or N, and up to 3 hydrogen atoms may be replaced by halogen; Ris absent when &#x2014;Y&#x2014;Z&#x2014;Ris attached to W, or is H or Cto Chydrocarbyl when &#x2014;Y&#x2014;Z&#x2014;Ris not attached to W; W is nitrogen; X is &#x2014;CH&#x2014;, &#x2014;O&#x2014; or &#x2014;NR&#x2014;, Rbeing H or Cto Calkyl; Y replaces a hydrogen atom on any of A, B, W and X, and is Cto Calkylene, in which one non-terminal carbon atom may be replaced by O; and Z is (II), (III), (IV), (V), (VI), or (VII) wherein R, Rand Rare independently H or Cto Chydrocarbyl, in which up to 3 carbon atoms may be replaced by O or N, and up to 3 hydrogen atoms may be replaced by halogen, and Q is H or methyl, or Q is linked to Ror Rto form a five-membered ring or Q is linked to Rto form a six-membered ring

Histamine H3 receptor ligands

Gastrin and cholecystokinin receptor ligands

Sulfonamides and sulfamides as H.sub.3 receptor antagonists

Gastrin and CCK antagonists

The compounds of the formula I ##STR1## and their pharmaceutical acceptable salts, which are defined herein, are ligands for cholecystokinin and/or gastrin receptors.

Bicyclo 2,2,2!octane derivatives

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Beds, United Kingdom

Elaine Anne Harper