University of California

Angiodynamics, Inc.

Elad Maor

Boris Rubinsky

James J Mitchell

William C Hamilton

Antoni Ivorra

Mary Phillips

Jacob Lavee

Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a balloon catheter with a particular electrode configuration. Also provided is a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.

Balloon catheter method for reducing restenosis via irreversible electroporation

Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically.

Extracellular matrix material created using non-thermal irreversible electroporation

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Berkeley, CA, United States of America

Elad Maor