Randox Laboratories Limited

El Ouard Benchikh

Stephen Peter Fitzgerald

Robert Ivan McConnell

John Victor Lamont

Andrew Philip Lowry

Robert Ivan Mcconnell

The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays for the detection of ractopamine, isoxsuprine and ritodrine. The haptens are prepared by reacting a phenylethanolamine derivative of formula D with a phenylalkylcarbonyl derivative of formula E: in which, in formula I, Zis a crosslinker and Zis H and, in formula II, Zis H and Zis a crosslinker.

Phenethanolamine-derived haptens, immunogens, antibodies and conjugates

Novel haptens, which can be conjugated to form immunogens, are of formula I, II or IIIwherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

Haptens, immunogens and antibodies to oxycodone and its metabolites

A solid state device for performing multi-analyte assays, comprises a substrate and a multiplicity of discrete reaction sites each bearing a ligand covalently bonded to the substrate, wherein the surface of the substrate between the reaction sites is inert with respect to analyte. Such a device may be obtained by a process of activating the surface of the substrate, and applying an array of ligands on to discrete areas on the surface.

Growing community of inventors

Co. Antrim, United Kingdom

El Ouard Benchikh