Genentech, Inc.

Ge Healthcare Bio-sciences Ab

F. Hoffmann-la Roche Ag

Ekta Mahajan

Edward Chan

Kelsey Dent

Terry Hudson

Neria Daniel

Klaus Gebauer

Eric Faldt

Joanna So

Jay Werber

Kapil Kothary

Eric FÄLDT

Described herein are bioreactor support structures configured to be used with containers having different designs, and methods for making and using such bioreactors. The support structures described herein may include two or more agitator motors and control systems or an adjustable-position agitator motor, a removable spacer and/or lid, multiple configurations for ports and probes, and multiple exhaust filter heating blankets. Also described herein are methods of manufacturing a multi-agitator motor or adjustable-position agitator motor bioreactor, as well as methods of modifying an existing support structure to be used with a container not originally designed to be used with the existing support structure, and methods for operating these bioreactors.

Bioreactors with multiple or adjustable-position agitator designs

The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products.

Method for chromatography reuse

The present invention relates to a device () for delivery of fluid, said device comprising at least two fluid ducts (-) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold () having an inlet end and an outlet end, each of said fluid ducts (-) comprising a pinch valve () for closing and opening the duct. According to the invention a check valve () is disposed in at least one of said fluid ducts (-) in the end thereof connected to the manifold ().

Device for delivery of sample fluid

Growing community of inventors

South San Francisco, CA, United States of America

Ekta Mahajan