Schering Aktiengesellschaft

Ekkehard Schillinger

Werner Skuballa

Helmut Vorbrueggen

Jorge Casals-Stenzel

Olaf Loge

Bernd Raduechel

Michael H Town

Walter Elger

Helmut Vorbruggen

Bernd Raduchel

Helmut Biere

Wolfgang Losert

Clemens Rufer

Norbert Schwarz

Hanns Ahrens

Ralph Schmiechen

Gerda Mannesmann

Eberhard Schroeder

Claus-Steffen Stuerzebecher

Michael-Harold Town

Henry Laurent

Ulrich Klar

Martin Haberey

Dieter Bittler

Karl-Heinz Thierauch

Martin Schneider

Eberhard Schroder

Bob Nieuweboer

Claus-Steffen Sturzebecher

Rudolf Weichert

VorbruHelmut

The invention relates to an antimetastatically acting agent consisting of Eptaloprost, Cicaprost or combinations of TXA.sub.2 antagonist and prostacyclin derivatives.

Antimetastically acting agents

Compounds of the formula ##STR1## wherein the 9-chlorine atom can be in the .alpha.-or .beta.-position,

Pharmaceutically active 9-chloroprostaglandins

A 9-chloroprostane of the formula ##STR1## wherein the 9-chlorine atom can be in the .alpha. or .beta.-position and R.sub.1, R.sub.4, R.sub.5, A, B, W, D and E are as described hereinafter which are useful as medical agents.

6-oxoprostaglandin E derivatives, process for their production and their

(5E)-13,14,18,18,19,19-hexadehydro-3-oxa-6a-carbaprostaglandin I.sub.2 derivatives of Formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are hydrogen or alkyl of 1-5 carbon atoms, and

Novel carbacyclins, processes for their preparation and their use as

Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is hydrogen or OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, ##STR2## or a heterocyclic residue; or R.sub.1 is NHR.sub.3 wherein R.sub.3 is an acid residue (acyl) or R.sub.2,

Carbacylcins, their preparation and use as medicinal agents

Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2 wherein R.sub.2 is hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, ##STR2## or a heterocyclic residue, or R.sub.1 is R.sub.3 wherein R.sub.3 is C.sub.1 -C.sub.10 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.6 -C.sub.10 -aryl, C.sub.7 -C.sub.14 -aralkyl or a heterocyclic residue,

Novel carbacyclins, processes for their production and their use as

Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR.sub.3, wherein R.sub.3 is an acid residue or hydrogen;

Novel carbacyclins, their preparation and use

Compounds of Formula I ##STR1## wherein R.sub.1 is a prostaglandin or prostacyclin residue;

Prostaglandins and prostacyclins, process for their preparation and

Azaprostacyclins of Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy,

Azaprostacyclins, their preparation and pharmaceutical use

Compounds of Formula I ##STR1## wherein X is oxygen or CH.sub.2 ;

Carbacyclins, their preparation and pharmacological use

Prostaglandins and prostacyclins, processer for their preparation and

Novel 6.beta.,7.beta.-methylene-17.alpha.-pregn-4-ene-21,17-carbolactones of Formula I ##STR1## wherein R and R' each is hydrogen or jointly form a methylene group. These exhibit a good antimineralocorticoid effect with low side effects.

6.beta.,7.beta.-Methylene-17.alpha.-pregn-4-ene-21,17-carbolactones,

Compounds of the formula ##STR1## wherein the 9-chlorine atom can be in the .alpha.- or .beta.-position,

Growing community of inventors

Berlin, Germany

Ekkehard Schillinger