Hoechst Aktiengesellschaft

Hoechst Aktiengesellachaft

Ekkehard Baader

Martin Bickel

Volkmar Gunzler-Pukall

Gerhard Beck

Stephan Henke

Dietrich Brocks

Volkmar Gunzler

Hartmut Hanauske-Abel

Gunther Wess

Gerrit Schubert

Heiner Jendralla

Kurt Kesseler

Bela Kerekjarto

Harald Burghard

Volkmar G unzler-Pukall

The invention relates 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.

2,4-and 2,5-bistetrazolylpyridines, a process for the preparation

The invention relates to N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides of the formula I ##STR1## wherein R.sup.1, R.sup.2, n, R.sup.1', R.sup.2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants.

N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamines

The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.

2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals

The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The invention also relates to a process for the preparation of the abovementioned compounds and to their use as medicaments, in particular as fibrosuppressants and immunosuppressants.

Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof

2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.

2,4- and 2,5-substituted pyridine-N-oxides, processes for their

The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fibrosuppressants and immunosuppressants.

Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for

The invention relates to oxalylamino acid derivatives of the formula I ##STR1## in which R and R' are identical or different and are C.sub.1 -C.sub.6 -alkyl or hydrogen,

Oxalylamino acid derivatives and their use as medicaments for inhibiting

Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use

Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compounds The invention relates to pyrimidine-4,6-dicarboxylic acid diamides of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can be employed as fibrosuppressants and immunosuppressants.

Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use

7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyhept-6-enoic acids, 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxyheptanoic acids of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, and the corresponding .delta.-lactones of the formula II ##STR2## processes for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.

7(1H-pyrrol-3-YL)-substituted 3,5-dihydroxyhept-6-enoic acids,

Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments

A process for the preparation of optically active 3-demethylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups.

Process for the preparation of optically active 3-demethylmevalonic acid

A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## (.beta.-hydroxy lactones) in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.

Optically active 3-demethylmevalonic acid derivatives, and intermediates

New 3,5-dihydroxy carboxylic acids and derivatives thereof, a process for the preparation thereof, the use thereof as pharmaceuticals, pharmaceutical products and intermediates 3,5-Dihydroxy carboxylic acids and derivatives thereof, of the formula I ##STR1## and the corresponding Lactones of the formula II ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X-Y have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formulae I and II are described.

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Konigstein/Taunus, Germany

Ekkehard Baader