Kyowa Hakko Bio Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Daiichi Fine Chemical Co., Ltd.

Kyowa Pharma Chemical Co., Ltd.

Eitora Yamamura

Tetsuo Nakano

Jun Ogawa

Akinori Ando

Shinji Kita

Kazuya Tsuzaki

Noboru Fujimoto

A prostaglandin production method according to the present invention comprises reacting an unsaturated fatty acid with cyclooxygenase in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandins at a high yield.

Prostaglandin production method

The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than &#xbd; of the weight average chain length of one ssRNA constituting the second chain.

Double-stranded ribonucleic acid for adjuvants

A process for efficiently producing optically active succinimide derivatives as key intermediates of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4&#x2032;(1&#x2032;H)-pyrrolo[1,2-a]pyrazine}-1&#x2032;,2,3&#x2032;,5(2&#x2032;H)-tetraone, which comprises the following reaction steps, and the step 2 is performed by using a non-animal-derived enzyme. 

Process for producing optically active succinimide derivatives

A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genusfrom a-derived plasmid having the nucleotide sequence set forth as SEQ ID NO: 73 and a plasmid or its DNA fragment having the nucleotide sequence set forth as SEQ ID NO: 74, and a DNA region replicable infrom an-derived plasmid or its DNA fragment. An aminoketone asymmetric reductase gene is inserted into the shuttle vector, transformants containing the vector are created, and the aminoketone asymmetric reductase and optically active aminoalcohols are produced.

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Takaoka, Japan

Eitora Yamamura