Nissan Chemical Industries Limited

Eitatsu Ikeda

Takeshi Mita

Mitsuaki Komoda

Ken-ichi Toyama

Manabu Yaosaka

Yuki Furukawa

Yoshihide Masuzawa

Kazushige Maeda

Motoyoshi Iwasa

Tsutomu Nawamaki

Yoshihiro Kudo

Jun Satow

Yuji Moriyama

Kazutaka Matoba

Chiaki Kawaguchi

Hiroaki Takahashi

Youko Yamada

Ken-Ichi Toyama

There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an &#x3b1;,&#x3b2;-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method. 

Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound

An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A, Aand Aindependently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., W is oxygen atom or sulfur atom, etc., X is halogen atom, C-Chaloalkyl, etc., Y is halogen atom, C-Calkyl, etc., Ris &#x2014;CH&#x2550;NOR, &#x2014;C(O)OR, &#x2014;C(O)NHR, phenyl substituted with (Z), D-14, D-52, D-53, D-55 to D-59, etc., Ris C-Calkyl, etc., Ris C-Calkyl, etc., Ris hydrogen atom, &#x2014;C(O)R, &#x2014;C(O)OR, etc., Ris C-Calkyl, &#x2014;CHR, C-Calkynyl, &#x2014;C(O)R, &#x2014;C(O)OR, etc., further when Ris &#x2014;CH&#x2550;NOR, &#x2014;C(O)ORor &#x2014;C(O)N(R)R, Rmay be hydrogen atom, Ris C-Chaloalkyl, etc., Ris cyano, &#x2014;OR, etc., Ris C-Calkyl, C-Chaloalkyl, C-Calkoxy C-Calkyl, C-Calkylthio C-Calkyl, C-Ccycloalkyl, C-Calkenyl, etc., Ris C-Calkyl, C-Chaloalkyl, &#x2014;C(O)Ror &#x2014;C(O)OR, etc., Ris C-Calkyl or C-Ccycloalkyl, etc., Z is halogen atom, cyano, nitro, C-Calkyl, C-Calkoxy, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

Isoxazoline-substituted benzamide compound and pesticide

There is provided a novel pest control agent, particularly an insecticide or miticide. A substituted isoxazoline compound of General Formula (1): where A, Aand Aindependently are CH or N, etc., X, Xand Xare independently are H, a halogen atom, etc., Yis H, etc., Ris &#x2014;C(O)R, &#x2014;C(S)R, Ris &#x2014;C(R)(R)&#x2014;S(O)R, &#x2014;C(R)(R)&#x2014;S(O)(R)&#x2550;NR, etc., Ris H, etc., Ris CF, CClF, etc., Ris H, etc., Ris H, etc., Ris H, etc., Ris Calkyl, etc., Ris H, etc., r is an integer of 0-2, t is an integer of 0 or 1; and a pest control agent comprising the compound or the salt thereof.

Substituted isoxazoline compound and pest control agent

There is provided a novel pest control agent, particularly an insecticide or miticide. A substituted dihydroazole compound of General Formula (1) or a salt thereof: where A, A, Aand Aare independently C&#x2014;Y or N, Ais &#x2014;CH&#x2014;, etc., Gis a benzene ring, etc., Gis G-1, G-6, G-9, etc., X is a halogen atom, Chaloalkyl, etc., Z is methyl, &#x2014;NH, etc., Ris &#x2014;C(O)R, etc., Ris Calkyl, etc., Ris H, Calkyl, etc., Ris Chaloalkyl, etc., Ris H, cyano, methyl, etc., m is an integer of 1, 2, 3, etc., n is an integer of 0 or 1; and a pest control agent comprising the compound or the salt thereof.

Substituted dihydroazole compound and pest control agent

A pesticide, particularly an insecticide or an acaricide, including a substituted isoxazoline compound of formula (1) or a salt thereof: wherein A, Aand Aindependently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., L is &#x2014;N(R)&#x2014;, or &#x2014;CH(R)N(R)&#x2014;, etc., X is halogen atom, C-Chaloalkyl, etc., Y is halogen atom, C-Calkyl, etc., Ris &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NHR, etc., Ris hydrogen atom, C-Chaloalkyl, &#x2014;C-Calkoxy C-Calkyl, cyano C-Calkyl, C-Calkenyl, C-Calkynyl, &#x2014;C(O)R, &#x2014;C(O)OR, etc., Ris C-Chaloalkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4. The pesticide containing these compounds.

Isoxazoline compound and pesticide

An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A, Aand Aindependently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., W is oxygen atom or sulfur atom, etc., X is halogen atom, C-Chaloalkyl, etc., Y is halogen atm, C-Calkyl, etc., Ris &#x2014;CH&#x2550;NOR, &#x2014;C(O)OR, &#x2014;C(O)NHR, phenyl substituted with (Z), D-14, D-52, D-53, D-55 to D-59, etc., Ris C-Calkyl, etc., Ris C-Calkyl, etc., Ris hydrogen atom, &#x2014;C(O)R, &#x2014;C(O)OR, etc., Ris C-Calkyl, &#x2014;CHR, C-Calkynyl, &#x2014;C(O)R, &#x2014;C(O)OR, etc., further when Ris &#x2014;CH&#x2550;NOR, &#x2014;C(O)ORor &#x2014;C(O)N(R)R, Rmay be hydrogen atom, Ris C-Chaloalkyl, etc., Ris cyano, &#x2014;OR, etc., Ris C-Calkyl, C-Chaloalkyl, C-Calkoxy C-Calkyl, C-Calkylthio C-Calkyl, C-Ccycloalkyl, C-Calkenyl, etc., Ris C-Calkyl, C-Chaloalkyl, &#x2014;C(O)Ror &#x2014;C(O)OR, etc., Ris C-Calkyl or C-Ccycloalkyl, etc., Z is halogen atom, cyano, nitro, C-Calkyl, C-Calkoxy, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

There is provided a novel pesticide, particularly an insecticide or an acaricide. A substituted isoxazoline compound of formula (1) or a salt thereof: wherein A, Aand Aindependently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., L is &#x2014;CH&#x2014;, &#x2014;C(CH)&#x2014;, &#x2014;CH(CN)&#x2014;, etc., X is halogen atom, C-Chaloalkyl, etc., Y is halogen atom, C-Calkyl, etc., Ris &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NHR, etc., Ris hydrogen atom, C-Chaloalkyl, &#x2014;C-Calkoxy C-Calkyl, cyano C-Calkyl, C-Calkenyl, C-Calkynyl, &#x2014;C(O)R, &#x2014;C(O)OR, etc., Ris C-Chaloalkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4. The pesticide containing these compounds.

A compound represented by the general formula (I) and a salt thereof: ##STR1## wherein: Rf represents a (C.sub.1 -C.sub.4)haloalkyl group; X.about.Y represents N.dbd.N or CH.dbd.N or the like; A represents a nitrogen atom or CH; Z represents an oxygen or sulfur atom; Rg represents a hydrogen or halogen atom and the like; R1, R2, R3, R4 and R5 are each independently represent a hydrogen or halogen atom or a nitro or cyano group or the like.

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Funabashi, Japan

Eitatsu Ikeda