Hisamitsu Pharmaceutical Company, Inc.

Eisuke Hatanaka

Naruhito Higo

Yasunori Takada

Yasunari Michinaka

Naoki Yamamoto

Takaaki Terahara

Hisakazu Kurita

Kazuki Kuriyama

Ryusuke Fudoji

Junji Noguchi

A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.

Microneedle sheet production method and microneedle sheet

A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

Patch

A patch comprising a support layer and an adhesive layer, wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.

Adhesive patch comprising diclofenac sodium

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Tsukuba, Japan

Eisuke Hatanaka