Terumo Kabushiki Kaisha

Eisuke Furuichi

Yasuo Kurosaki

Hiroshi Goto

Hiroshi Gotou

Ryosuke Suzuki

A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The method includes moving a drive shaft relative to at least one of a hub of the balloon catheter and an interlocking member. The drive shaft is configured to rotate the balloon catheter about an axis of the balloon. The method fixing the drive shaft to the proximal end of the hub or to the opening of the interlocking member by frictional force, and applying a coating solution containing the drug to the outer surface of the balloon from a dispensing tube while gradually moving the dispensing tube in the axial direction and simultaneously rotating the drive shaft to rotate the balloon catheter around the axis of the balloon catheter.

Balloon coating method, balloon rotating method, and balloon coating device

A balloon coating method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes an application step where a vertically extending dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when an opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.

Balloon coating method

A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter, wherein the balloon catheter includes an elongate shaft possessing a distal portion at which is provided the balloon which is inflatable. The balloon coating method includes: holding the shaft on a support part capable of rotating about an axis of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon together with the support part, thereby to coat the outer surface of the balloon with the coating liquid.

Balloon coating method, balloon rotating method and balloon coating apparatus

A balloon coating method and apparatus are disclosed which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug. The method includes pulling a distal tip of the balloon in an axial direction of the balloon to straighten a bend of the balloon; rotating the balloon about an axis of the balloon; and coating the outer surface of the balloon with a coating liquid.

Balloon coating method and balloon coating apparatus

A balloon coating method is disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method includes an application step in which, where a pipe-shaped dispensing tube formed from a polyolefin for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the end portion side of the dispensing tube is placed in contact with the outer surface of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.

Balloon coating method, coat layer control method and balloon coating device

Disclosed herein is a balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon catheter including the balloon which is inflatable and provided on a distal portion of an elongate shaft. The balloon coating method includes: accommodating the shaft in a groove portion formed in a support base to extend rectilinearly, and closing at least part of the groove portion with a lid portion, thereby to support the shaft such that the shaft can be rotated within the groove portion; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to coat the outer surface of the balloon with the coating liquid.

A balloon coating method and a balloon coating apparatus are disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method including fixing a connection portion between the balloon and an inner tube passing through an inside of the balloon, and moving a dispensing tube relative to the balloon in an axial direction of the balloon while rotating the balloon about an axis of the balloon and while also dispensing the coating liquid containing the water-insoluble drug from the dispensing tube to apply the coating liquid to the outer surface of the balloon.

A balloon coating method for forming a coating layer on the outer surface of a balloon of a balloon catheter includes: inserting a core member into a guide wire lumen penetrating the balloon, disposing a proximal portion of the core member on a proximal side of a region of inflation of the balloon, with a distal portion of the core member protruded distally beyond a distal opening portion of the guide wire lumen, and fixing by clamping together with the core member a part of the balloon catheter that is on a distal side of the region of inflation; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to apply the coating liquid to the outer surface of the balloon.

Balloon coating method and balloon rotating method

A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter. The method includes applying a first rotation force to the balloon catheter proximal to the balloon of the balloon catheter and applying a second rotation force to the balloon catheter distal to the balloon of the balloon catheter. The first rotation speed is the same as the second rotation speed. The method includes applying a coating solution containing the drug to the outer surface of the balloon from a dispensing tube while gradually moving the dispensing tube in the axial direction and simultaneously applying the first and second rotation forces to rotate the balloon catheter around the longitudinal axis of the balloon catheter.

A method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes supplying a coating solution containing a drug and a solvent through an end portion of a flexible dispensing tube with an opening portion for discharging the coating solution through the end portion of the flexible dispensing tube; keeping in contact an opening portion-formed end portion side of the dispensing tube with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon; rotating the balloon about an axis of the balloon; and discharging the coating solution through the opening portion and applying the coating solution to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.

Positioning method for balloon coating

A balloon coating method and a balloon coating apparatus are disclosed by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set. The balloon coating method can include moving a coating section for applying a coating liquid containing a drug relative to the balloon in the direction of an axis, while rotating the balloon about the axis of the balloon, thereby to apply the coating liquid to an outer surface of the balloon; detecting the distance of a dried part where the coating liquid applied to the outer surface of the balloon has been dried from the coating section; and controlling moving velocity of the coating section relative to the balloon in such a manner that the distance of the dried part from the coating section is maintained at a preliminarily set designated distance.

A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter includes: inserting a core member into a guide wire lumen penetrating the balloon, disposing a proximal portion of the core member on a proximal side of a region of inflation of the balloon, with a distal portion of the core member protruded distally beyond a distal opening portion of the guide wire lumen, and fixing by clamping together with the core member a part of the balloon catheter that is on a distal side of the region of inflation; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to apply the coating liquid to the outer surface of the balloon.

A balloon coating method and apparatus are disclosed which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug. The balloon coating method and the balloon coating apparatus are for forming a coating layer on a surface of a balloon. The balloon coating method includes a pulling step of pulling the balloon in the direction of an axis of the balloon to thereby straighten a bend of the balloon, and a coating step of rotating the balloon about the axis of the balloon, with the balloon maintained in the bend-straightened state, and coating an outer surface of the balloon with a coating liquid containing a drug.

A positioning method for balloon coating by which the thickness and morphological form of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which a dispensing tube is moved, from a state of non-contact with the balloon, in a direction intersecting the extending direction of the dispensing tube, and an opening portion-formed end portion side of the dispensing tube formed at its end portion with an opening portion for discharging a coating solution is thereby placed in contact with the outer surface of the balloon.

A balloon coating method is disclosed, which includes an application step in which, where a flexible dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction X of the balloon.

Growing community of inventors

Kanagawa, Japan

Eisuke Furuichi