Japan Science and Technology Corporation

Idemitsu Petrochemical Co., Ltd.

Nipro Corporation

Nec Corporation

Praxair Technology, Inc.

Nippon Oil Fats Co., Ltd.

The University of Texas System

Japan Science and Technology Agency

Agency of Industrial Science and Technology

Ministry of International Trade & Industry

Taiho Pharmaceutical Company Limited

Yoshitomi Pharmaceutical Industries, Ltd.

Waseda University

Union Carbide Industrial Gases Technology Corporation

Jcr Pharmaceuticals Co., Ltd.

Eishun Tsuchida

Shinji Takeoka

Hiroyuki Nishide

Teruyuki Komatsu

Kimihisa Yamamoto

Keitaro Sou

Hiromi Sakai

Hiroyoshi Kawakami

Etsuo Hasegawa

Mitsutoshi Jikei

Toshiya Kai

Makoto Sato

Naohisa Katayama

Akito Nakagawa

Katsura Mori

Haruki Ohkawa

Naomi Ohmichi

Atsushi Kobayashi

Toshihiko Nishiyama

Norihisa Kobayashi

Takashi Fukaumi

Yoshihiko Saiki

Kenichi Oyaizu

Masao Kato

Hiroyuki Ohno

Kei Saito

Hachiro Nakanishi

William T Phillips

Kiyoshi Eshima

Takanao Suzuki

Hiro Matsuda

Kiyoshi Yoshimura

Masashi Ohi

Beth A Goins

Yoshinori Kida

Kenichi Tomiyama

Yoh-ichi Matsushita

Junichi Yokoe

Ippei Fukutomi

Akihisa Saitoh

Hiroto Onuma

Junya Katoh

Kumihisa Yamamoto

Mikimasa Takisada

Yukiko Sasame

Yoshitaka Fujishima

Yuji Orihashi

Shu Yoshida

Shu YHoshida

Yosuke Kumaki

Tomoyasu Atoji

Yuji Teramura

Yasuko Matsukawa

Keitaro So

Ippei Hukutomi

Yuko Azuma

Shinji Forest Tamagawa 404 Takeoka

The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.

Bone marrow-directing drug delivery materials and their applications

A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.

Porphyrin compound, albumin inclusion compound thereof and artificial oxygen carrier

A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.

Pharmaceutical composition containing artificial oxygen carrier

The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.

Artificial oxygen carrier and production method thereof

A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises: 

Porphyrin-metal complexes and oxygen infusions containing the same

An oxygen carrier system includes an artificial oxygen carrier including hemoglobin vesicles encapsulating hemoglobin and an intermediate electron mediator having a standard electrode potential of 0.05 V to 0.56 V (vs. the standard hydrogen electrode) in the vesicles, and a reducing agent which is added to an external aqueous phase of the hemoglobin vesicle to reduce methemoglobin when the hemoglobin encapsulated in the hemoglobin vesicle is oxidized to the methemoglobin. The reducing agent has, as an active component, at least one compound selected from the group consisting of a thiol compound and a reducing sugar.

Oxygen carrier system, artificial oxygen carrier, and reducing agent

Provided is a zwitterionic lipid compound represented by formula (I) given below:In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH, and each other R is H.

Zwitterionic lipid compound and uses thereof

As a negatively charged lipid that can stably add negative charges to the surface of vesicles without side effects, the carboxyl acid-type lipid of the following general formula [1]:[wherein R, Rand Rrepresent substituents of which one is represented by the following general formula [X]:(wherein M is a hydrogen atom or monovalent cation, and m is an integer of 1 to 5 that represents the methylene chain length), and the other two are chained hydrocarbon groups; A, Aand Aare the same or different substituents selected from the group consisting of C(O)O, CONH or NHCO; and n is an integer of 1 to 3 that represents the methylene chain length) is provided.

Carboxylic acid-type lipid

An amphiphilic compound having a dendritic branch structure represented by general formula (I):In the formula (I), Ris a hydrophilic group; Rand Rare independently a hydrophobic group; and n is an integer of 1 to 4. This amphiphilic compound is capable of stably fixing a water-soluble polymer onto a surface structure by taking advantage of intermolecular interaction, thereby enabling the water-soluble polymer to be carried thereon without giving any damage to the function thereof.

Amphiphilic compounds having a dendritic branch structure

A method and an apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method includes adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.

Photoreduction method for hemoglobin-vesicle

The present invention provides a method for preserving an oxygen infusion containing an aqueous suspension of molecular assemblies which contain hemoglobin or a heme compound, by:

Method of preserving oxygen infusions

The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of &minus;1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.

Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative

A porphyrin metal complex-albumin inclusion compound wherein a substituted porphyrin metal complex comprising, as a central, coordinated metal, a transitional metal belonging to the fourth or fifth period of the periodic law, is included in the albumin, and an oxygen carrier composition comprising said inclusion compound as an active ingredient. The compound functions as an oxygen carrier which is superior in biocompatibility, capable of adsorption and desorption of oxygen under physiological conditions, and is rather easily produced at an industrial scale.

Porphyrin metal complex-albumin inclusion compound and oxygen carrier

The solid electrolytic capacitor comprises a sealed capacitor element having, as a solid electrolyte layer, a heat resistant conductive layer formed on a dielectric oxide film. The heat resistant conducting polymer layer contains water, and the capacitor element inside is substantially oxygen-free. A cathode conductive layer is provided on the capacitor element and then both an external cathode lead and an external anode lead are mounted on the capacitor element. Water is supplied to the conducting polymer layer of the capacitor element such that the conducting polymer layer inside contains water. The capacitor element is then sealed such that water is held within the heat resistant conducting polymer layer and that the capacitor element inside is substantially oxygen-free. The step of supplying water is carried out by dipping the heat resistant conducting polymer layer in water or heavy water or exposed to water-containing inert gas. The capacitor element is sealed in a water-containing oxygen-free inert gas atmosphere. The resulting capacitor has excellent heat resistance.

Heat resistant conducting polymer, solid electrolytic capacitor using

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Tokyo, Japan

Eishun Tsuchida