Fujisawa Pharmaceutical Company, Ltd.

Eisaku Tsujii

Masakuni Okuhara

Masami Ezaki

Masanori Okamoto

Hiroshi Hatanaka

Shigehiro Takase

Nobuharu Shigematsu

Seiji Hashimoto

Michiyo Miyauchi

Masashi Hashimoto

Teruo Kyoto Oku

Hirokazu Tanaka

Kozo Sawada

Yasuhisa Tsurumi

Tsutomu Kaizu

Kunio Nakahara

Yasuhiko Shinguh

Noriaki Inamura

Yoshitada Notsu

A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.

Antimicrobial agent, FR109615 and production thereof

A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.

WS7622A mono- or di-sulfate, process for preparation thereof and use

WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.

WS7622A mono- or di- sulfate, process for preparation thereof and use

A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.

Prophylactic/therapeutic composition for disseminated intravascular

A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.

WS7622A, B, C and D substances, derivatives thereof, processes for

A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each lower alkyl, R.sup.4 is hydrogen or hydroxy, and a heavy solid line means a double bond when R.sup.4 is hydrogen and a single bond when R.sup.4 is hydroxy is useful in the treatment of diseases caused by reactive oxygen species and organic radicals.

Pharmaceutically useful 5-hydroxy-2,3-dihydro-benzofurans and

(1R, 2S)-2-Aminocyclopentanecarboxylic acid and its salts useful as antimicrobial agents.

The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.

The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,

Growing community of inventors

Tsukuba, Japan

Eisaku Tsujii