Dana-Farber-Cancer Institute Inc.

Eirik Helseth

Joseph G Sodroski

William A Haseltine

Craig D Furman

Udy Olshevsky

Richard Wyatt

Markus Thali

Immunogenic peptides containing amino acid residues which define a binding site to a CD4 receptor are disclosed. Antibodies to these peptides are also disclosed. Methods of reducing the ability of a gp12O env protein to bind to CD4 are also disclosed. Methods of treatment and prophylaxis using these antibodies and peptides are also described.

Immunogenic peptides, antibodies and uses thereof relating to CD4

Immunogenic peptides containing amino acid residues which define a binding site to a CD4 receptor are disclosed. Antibodies to these peptides are also disclosed. Methods of reducing the ability of a gp120 env protein to bind to CD4 are also disclosed. Methods of treatment and prophylaxis using these antibodies and peptides are also described.

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Trondheim, Norway

Eirik Helseth