Nisshin Flour Milling Co., Ltd.

Einosuke Sakurai

Toshiji Sugai

Hiroyasu Koyama

Hiroaki Yamada

Katsutoshi Miura

Fumiko Hamaguchi

Tatsuo Nagasaka

Norio Oshida

Hiroaki Satoh

Masato Horigome

Koichi Itoh

Hiroshi Sakai

Shinji Yokoyama

Tamiko Hamada

Kazumi Nishimura

Tomomi Tonoike

Yoji Mimaki

Yukiko Muraki

Hirohiko Komatsu

Rie Hakamada

Pyridinecarboxamide derivatives

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.3 alkyl or diphenylmethyl; Y is --NH(CH.sub.2).sub.n --R.sub.2 ; R.sub.2 is OH or --ONO.sub.2 ; m is 2 or 3; and n is 9 to 13 or physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing and hypotensive actions and can be used for the therapy or prevention of diseases in the cardiovascular system.

Pyridinecarboxylic acid amide derivatives and pharmaceutical

The use of 1-phenoxycarbonyl-2-pyrrolidinone derivatives as an anti-platelet aggregating agent. The derivatives are of the formula ##STR1## wherein R is a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a nitro group or a halogen atom and n is 0, 1 or 2.

Anti-platelet aggregating agent

1-Phenoxycarbonyl-2-pyrrolidinone derivatives of formula (I) or (I') are disclosed. ##STR1## wherein R is a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a nitro group or a halogen atom and n is 1 or 2, and R' is the same as R, but including further a hydrogen atom. The compounds of formula (I') are useful as nootropic agents.

1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents

Pyrrolidine derivatives of formula (I) are disclosed. ##STR1## wherein the ring A represents the following heterocyclic ring ##STR2## The compounds of formula (I) are useful as nootropic agents.

Pyrrolidine derivatives as nootropic agents

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl;

Nicotinic acid derivatives and pharmaceutical compositions comprising

Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen; C.sub.1 -C.sub.6 alkyl; C.sub.3 -C.sub.6 cycloalkyl or diphenylmethyl;

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Saitama, Japan

Einosuke Sakurai