Adama Makhteshim, Ltd.

Assia Chemical Industries Ltd.

Einat Kisin-Finfer

Tamar Nidam

Maytal Piran

Ariel Mittelman

Rotem Sella-Erez

Sharona Shachan-Tov

Jonathan Enav

Motti Erlich

Marina Yarovoy

Victoria Machtey

Sagit Azran

Xi Zhen

Pingping Tang

Abed Masarwa

Natali Ashush

The invention relates to a method for the preparation of 2-aminobiphenyls, key intermediates in the preparation of compounds of interest in the agrochemical industry. The process comprises reacting an ortho-substituted aniline and a phenylboro derivative in the presence of a base and a palladium catalyst, said palladium catalyst comprising a palladium source and a biphenyl phosphine ligand of formula (III) or a salt thereof.

Process for the preparation of biphenylamines

Solid state forms of Valbenazine, Valbenazine salts, processes for preparation thereof and pharmaceutical compositions thereof are disclosed. Processes for the preparation of Valbenazine and intermediates in the preparation thereof are further described.

Solid state forms of valbenazine

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Hod Hasharon, Israel

Einat Kisin-Finfer