Siemens Aktiengesellschaft

Gsi Helmholtzzentrum Fur Schwerionenforschung Gmbh

Gsi Helmholtzzentrum Fuer Schwerionenforschung Gmbh

Forschungszentrum Dresden-rossendorf E.v.

Siemens Healthcare Gmbh

Seimens Aktiengesellschaft

Gesellschaft Fur Schwerionenforschung Mbh

Heidelberger Ionenstrahl-therapie (hit) Betriebs-gesellschaft Am Universitatsklinikum

Gsi Helmfoltzzentrum Fur Schwerinonenforschung Gmbh

Gsi Helmholtzzentrum Fur Schwerionenforschuntg Gmbh

Heidelberger Ionenstrahltherapie (hit) Betriebs-gesellschaft Am Universitätsklinikum Heidelberg Mbh

Varian Medical Systems Particle Therapy Gmbh

Helmholtz-zentrum Dresden-rossendorf E.v.

Heidelberg Ionenstrahl-therapie (hit) Betriebs-gesellschaft Am Universitätsklinikum Heidelberg Mbh

Eike Rietzel

Christoph Bert

Leo John Grady

Ali Kamen

Alexander Gemmel

Gerhard Kraft

Andres Sommer

Sven Oliver Grözinger

Thilo Elsässer

Ali Khamene

Klaus Herrmann

Nami Saito

Oliver Thilmann

Johann Kim

Wenjing Chen

Thomas Hansmann

Jörg Bohsung

Robert Neuhauser

Robert Kagermeier

Gabriel Haras

Bernd Schweizer

Thomas Boettger

Thomas Haberer

Dietmar Sierk

Tim Use

Steffen Schröter

Wolfgang Enghardt

Stefan Käpplinger

Iwan Kawrakow

Torsten Zeuner

Katia Parodi

Martin Rohregger

Jürgen Holstegge

Stefan Hüttenberger

Matthias Saar

Sven Oliver GRÖZINGER

Thilo ELSÄSSER

Alexander Schmidt

Marie Vidal

The device relates to a method and a device () for determining an irradiation plan for a particle irradiation unit (). In the method, a target volume () within a test object () is irradiated with a particle beam () using the particle irradiation unit () according to the irradiation plan. The radiation plan is determined in order to apply the energy of the particle beam () according to a predetermined dose distribution in the target volume (), the target volume () and the predetermined dose distribution being pre-set. When determining the irradiation plan, irradiation duration is also taken into account, the irradiation plan being determined such that the irradiation duration is as short as possible.

Method and device for determining an irradiation plan for a particle irradiation system

A target volume within a test object is irradiated according to an irradiation plan with a particle beam using a particle irradiation unit. The irradiation plan is determined in order to apply the energy of the particle beam in the target volume according to a predetermined dose distribution. In addition, a boundary condition is specified for at least one of the isoenergy layers and the irradiation plan is additionally specified such that the boundary condition is met for the at least one isoenergy layer. The boundary condition includes one or more of a minimum boundary energy, a maximum boundary energy, a minimum grid point number, a minimum total particle number, a minimum total dose, a minimum dose contribution to a total dose to be administered, a minimum contribution to a target function which is calculated for determining the irradiation plan, and a minimum dose compensation error.

Determining an irradiation plan for a particle irradiation unit

A method for determining an irradiation plan includes specifying a target volume to be irradiated and a condition to be fulfilled, and implementing a first optimization. Implementing the first optimization includes providing a first data record, in which the target volume is mapped, and determining a first parameter set for the irradiation planning by implementing a first optimization algorithm. The first parameter set is optimized with respect to the condition to be fulfilled by using the first data record. The method also includes implementing a second optimization that includes providing a second data record that has a higher resolution than the first data record, determining a second parameter set by implementing a second optimization algorithm. The second parameter set is optimized with respect to the condition to be fulfilled by using the second data record and using the first parameter set. The method also includes generating an irradiation planning data record from the second parameter set.

Method for determining an irradiation plan

The idea concerns irradiation of a target volume (), wherein intensities for target points () are determined which are sequentially approached by a beam, comprising the following steps: detecting a volume () to be protected, wherein a dose generated by irradiating a target volume () does not exceed a predetermined maximum value; determining intensities for target points () in such a way that within the volume () to be protected the generated dose does not exceed the predetermined maximum value, wherein a dose contribution data record is used for determining the intensities, which dose contribution data record comprises the dose generated at other spots () by directing the beam () on one of the target points () with a predetermined intensity.

Irradiation of a target volume, taking into account a volume to be protected

A method for irradiation treatment planning for a target volume to be irradiated includes specifying a plurality of data sets. The target volume to be irradiated is depicted in each data set of the plurality of data sets. The data sets differ in that the target volume has another position and/or shape. A data set is selected from the plurality of the data sets and other data sets are registered to the selected data set. The method includes forming an amalgamation of the depicted target volumes using the registrations of the other data sets to the selected data set, and determining an area at risk in the selected data set. The method includes modifying the amalgamation of the target volumes such that the area at risk is excluded from the amalgamation of the depicted target volumes. An irradiation treatment plan is calculated using the modified amalgamation of the target volumes.

Method and device for irradiation treatment planning

A method for producing an irradiation plan for a target volume includes preparing a modulation curve that characterizes modulation of particle numbers at target points in the target volume that lie one behind another in a direction of the beam. The method also includes determining a current position of the target volume and defining a plurality of target points that fully cover the target volume in the current position. Particle numbers are assigned to the plurality of current target points using the modulation curve.

Irradiation planning for particle therapy

An irradiation plan for a particle irradiation unit is determined in a first run based on a specified target volume in a test object and a specified dose distribution to apply the particle beam in the target volume. The target volume includes a plurality of isoenergy layers. The irradiation plan may be determined in a second run with an additional condition that at least one of the isoenergy layers, determined according to one or more criteria, is not irradiated. Alternatively, the irradiation plan may be determined in a second run with an additional condition that only certain isoenergy layers, determined according to one or more criteria, are irradiated.

Method and device for determining an irradiation plan for a particle irradiation unit

To control of an irradiation installation, a particle beam is generated with a beam intensity, and a beam quality of the particle beam is monitored with a beam monitoring device. One of several adjustable measurement ranges is selected, wherein the measurement range of the beam monitoring device is set depending on the beam intensity of the particle beam and/or depending on a particle count to be applied.

Irradiation installation and control method for controlling same

The present disclosure relates to a particle energy modulating device for variably changing the energy of the particles of a particle beam. The particle energy modulating device has a variable energy varying device with a control value correcting device for correcting a supplied control value. The control value correcting device corrects the supplied control values through the use of previously determined calibration data.

Energy modulator

The invention concerns a process for the deposition of an intended dose distribution in a cyclically moved target region moving cyclically () by means of multiple irradiations with a beam () approaching matrix points of a target matrix in at least two scannings, wherein in each of the scannings, matrix points are approached sequentially. It is characterized through the steps: establishing the maximal tolerance level for local deviation from the intended dose distribution, de-synchronizing the sequence of the irradiation and the cyclical motion of the target region (), and partitioning the irradiation of the target region () in a sufficient number of scannings such that local deviations from the intended dose distribution correspond at most to the maximal tolerance level of deviation from the intended dose distribution. Furthermore, the invention also concerns an irradiation apparatus for executing a process of this type and a process for determining the control parameters for said irradiation apparatus.

Deposition of an intended dose distribution in a cyclically moved target area

The invention relates to a method for checking an irradiation installation in which a dose distribution is deposited in a target object by means of a treatment beam, said method comprising the following steps: an irradiation planning data record optimized for the irradiation of a moving target volume is provided; a movement signal that reproduces a movement of the target volume is provided; a phantom is irradiated, said phantom being formed for detecting a dose distribution deposited in the phantom during or after the irradiation, using the control parameters stored at the irradiation planning data record and the movement signal; a dose distribution deposited in the phantom is determined; a dose distribution to be expected is calculated on the basis of parameters that are related to the control of the irradiation installation during the irradiation; and the determined dose distribution deposited in the phantom is compared to the calculated dose distribution to be expected. The invention also relates to a corresponding device and an irridation installation comprising such a device.

Method and device for checking an irradiation planning system, and irradiation system

A device for planning an irradiation is provided. The device includes an evaluation module with an input for receiving input data, a memory and an output for outputting determined output data. The evaluation module is designed for using the input data that includes the type and number of the imaging units present, variables characterizing the tumor and/or variables characterizing the patient, in order to determine the output data that includes the type of the imaging unit, the frequency of use of the imaging unit and/or the parameters for setting the imaging unit to be used in the form of an imaging plan with the aid of a functional relationship, which is based on experience, stored in the memory.

Method and device for planning a treatment

A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.

Phantom for the experimental in-vitro validation of radiation procedures under the influence of motion, taking into account the biological effective dose

A method for irradiating a target volume includes defining a target region having a plurality of target points. The target points are individually approachable. The method includes defining a number of rescanning passes, in which the target region is scanned multiple times, such that the plurality of target points of the target region is approached variously often during the rescanning passes. At least some target points of the plurality of target points are not approached in all of the rescanning passes. The approaching of the plurality of target points is distributed among the rescanning passes such that for a target point of the plurality of target points that is not approached in all of the rescanning passes, at least one further rescanning pass, in which the target point is not approached, is located before a final rescanning pass, in which the target point is approached.

Irradiation or irradiation planning system for a rescanning method using a particle beam

A radiation therapy system for irradiating a target volume with a particle beam is provided. The radiation therapy system includes a radiation source that is operable to output an adjustable irradiation field that includes a particle beam that is scanned point by point over the target volume. A 3D imaging device may obtain a 3D radiation treatment data set in a radiation treatment phase. An adaptation unit adapts the irradiation field to a change in position and/or shape of the target volume in the radiation treatment phase. The adaptation unit compares the 3D radiation treatment data set with a 3D planning image data set furnished and obtains a transformation that describes the change in position and/or shape of the target volume. The adaptation unit transforms an irradiation field based on the transformation.

Radiation therapy system and method for adapting an irradiation field

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Darmstadt, Germany

Eike Rietzel