Bayer Aktiengesellschaft

Wayne State University

Baker Aktiengesellshaft

Eike Moller

Harald Horstmann

Egbert Wehinger

Karl Meng

Friedel Seuter

Karl-August Meng, Deceased

Karl Meng, Deceased

Horst Meyer

Bernward Garthoff

Kenneth V Honn

Wolf-Dieter Busse

By Matthias Meng, Legal Representative

A therapeutic method for reducing metastasis is disclosed. The method involves administering a therapeutically effective amount of 3-methyl-1-[2-(2-naphthyloxy)-ethyl]-2-pyrazolin-5-one or a pharmaceutically acceptable salt.

Method for treating human tumor cell metastasis

The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and methods for the use of said alkenoic acid amides and the compositions containing them. In addition, the invention includes the intermediate carbonyl compounds of Formula (II) and the intermediate alkenoic acids of Formula (V) as well as methods for their preparation.

New imidazoazole-alkenoic acid amide compounds, intermediate products

Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, lower alkyl or amino;

Pyrazol-5-ones

The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said compounds and compositions as antithrombotic agents and thrombolytic agents.

Imidazo[2,1-b]-[1,3,4]-thiadiazole compounds, composition and their

Pyrazoles of the formula ##STR1## wherein

4-Substituted pyrazoles

Pyrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable nontoxic salts thereof wherein R is hydrogen, trifluoromethyl or alkyl;

Pyrazole derivatives

5-Sulphonyloxy pyrazole derivatives

Pyrazoles of the formula ##STR1## wherein R is hydrogen, alkyl, trifluoromethyl, aryl, aralkyl or a heterocycle;

1-Substituted pyrazoles

Pyrazoles of the formula ##STR1## wherein R is hydrogen, alkyl, aryl, aralkyl, trifluoromethyl or a heterocycle;

1-Substituted pyrazole-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen or amino;

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Wuppertal, Germany

Eike Moller