Mitsubishi Petrochemical Company Limited

Eiji Taniyama

Takashi Kurihara

Sachio Hirose

Makoto Imanari

Hiroshi Iwane

Makoto Takeda

Kazuhiko Konno

Kunimasa Takahashi

Yosio Hayasi

Yuji Ozawa

Tetsuo Sekiya

There is disclosed a novel .gamma.-carboxyglutamic acid, a method for preparing the same and a method for preparing Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts of these, which comprises introducing .gamma.-carboxyglutamic acid in a peptide synthetic method of human osteocalcin by use of a protected L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof.

Amino acid derivative, method for preparing the same and method for

Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts thereof are prepared by introducing .gamma.-carboxyglutamic acid into the amino acid sequence of said osteocalcin by employing a protective L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof in the appropriate position in the reacting sequence of amino acids which form the osteocalcin.

Y-carboxyglutamate derivative, method for preparing the same and method

A process for producing a halobiphenyl derivative represented by the following formula (I) comprises dehydrogenating a cyclohexylhalobenzene represented by the following formula (II) under such conditions that substantially no dehalogenation occurs. ##STR1## wherein X represents a halogen atom, and each of R.sup.1 and R.sup.2 independently represents a group represented by the formula ##STR2## wherein A represents carboxyl or an alkoxycarbonyl group and R represents a hydrogen atom or a lower alkyl group; an alkylcarbonyl; alkenyl; alkynyl; alkyl; aryl; arylcarbonyl; hydroxyalkyl; cyanoalkyl or cyanoalkenyl group.

Process for producing biphenyl derivatives

A wood preservative composition for control of wood decay by fungi, which comprises 2H-benzopyran-2-spiro-3'-phthalide or its derivatives such as 6-methyl-2H-benzopyran-2-spiro-3'-phthalide or benzo[f]-2H-benzopyran-2-spiro-3'-phthalide as an active ingredient. The active ingredient has extremely low mammalian toxicity, and exhibits an excellent wood-decay controlling effect.

Wood preservatives and method for wood preservation treatment

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Ibaraki, Japan

Eiji Taniyama