Jsr Corporation

Jsr Life Sciences Corporation

Eiji Takamoto

Kouji Tamori

Toshihiro Ogawa

Mitsuhiro Murata

Tetsuo Fukuta

Masaru Ueno

Takahiro Kawai

Kiyoshi Kasai

Satoshi Katayose

Hirokazu Kai

Tomohiro Uetsuhara

To provide a solid-phase carrier that has extremely low nonspecific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using the solid-phase carrier. A method for capturing a target substance, including: a step for preparing a solid-phase carrier for capturing a target substance, the carrier having a base material, at least a portion of the surface thereof being formed of or coated with a saccharide, and having a linker of 5-100 atoms having a reactive functional group for binding a ligand that specifically binds to the target substance, wherein the saccharide is chemically bound to the linker; a step for binding the ligand to the solid-phase carrier to obtain a solid-phase carrier having a ligand bound thereto; and a step for bringing the solid-phase carrier having the ligand bound thereto into contact with a sample containing the target substance that specifically binds to the ligand.

Method for capturing target substance, solid-phase carrier for capturing target substance, and method for producing solid-phase carrier

A nonspecific adsorption inhibitor of a substance relating to a living body, which inhibits nonspecific adsorption of a substance relating to a living body such as various species of proteins which are used in clinical diagnostic agents, clinical diagnosis devices, biochips and the like, and a method for coating an article using said nonspecific adsorption inhibitor.

Nonspecific adsorption inhibitor of substance relating to living body and method for coating article

A non-specific adsorption inhibitor includes a water-soluble polymer obtained by polymerizing a monomer unit that includes a monomer (A) that forms a polymer that has a lower critical solution temperature (LCST) of 80&#xb0; C. or less in an aqueous solution under normal pressure when subjected to homopolymerization, and a monomer (B) that forms a polymer that does not have the LCST in an aqueous solution under normal pressure when subjected to homopolymerization.

Non-specific adsorption inhibitor

The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5&#xb0; to 60&#xb0;. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.

Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same

A method for producing a non-specific adsorption inhibitor includes reacting (A) a tosylated compound of polyoxyethylene monomethyl ether with (B) a polyamine having either an amino group or imino group (&#x2014;NH&#x2014;), or both, in total of 3 to 12.

Non-specific adsorption inhibitor, probe-bonded particles, and method for producing the same

A non-specific adsorption inhibitor of formula (1), wherein n is a real number of 4 to 2,000, Rand Rindividually represent a hydrogen atom or a group comprising 1 to 11 amino group(s) or imino group(s), or both, provided that the total number of amino groups and imino groups contained in Rand Ris 2 to 11. Non-specific adsorption inhibitor composition, probe-bonded particles.

Organic polymer particles having a structure shown by the following formula (1) are disclosed. wherein A represents an alkylidene group, an alkylene group, a cyclohexylene group, or a phenylene group, and B represents a linear or branched alkylene group or an alkylidene group having 1 to 6 carbon atoms.

Organic polymer-magnetic particles and process for producing same

A method for producing magnetic particles includes forming a hydrophobic first polymer layer on the surface of a mother particle containing superparamagnetic particles, forming a second polymer layer having glycidyl groups at least on its surface on the first polymer layer, and introducing a polar group containing one or more of at least one atom selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom by chemically modifying the glycidyl groups.

Growing community of inventors

Tsuchiura, Japan

Eiji Takamoto