The Green Cross Corporation

Eiji Sako

Tadakazu Suyama

Yasuo Ueda

Yoshio Kagitani

Nobuhiko Komatsu

Daisuke Satoh

Hisasi Sasamoto

Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2-acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding 11-reactive compound with a reactive sulfur compound to form 11-sulfino compounds and, if desired, oxidizing the 11-sulfino compounds to obtain 11-sulfo compound.

Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof

A medical appliance suitable for use in direct or indirect contact with blood, such as an artificial valve, artificial blood vessel, blood transfusion set, solution infusion set, or blood bag characterized by being composed of 100 parts by weight of polyvinyl chloride and as plasticizer 50 to 100 parts by weight of thermoplastic polyurethane of the polyester type, said polyurethane having a softening point of about 70.degree.C and giving no spot other than that of the origin at the same position loaded the test sample onto the plate in thin-layer chromatogram.

Medical appliance made of plastic

Growing community of inventors

Osaka, Japan

Eiji Sako