Otsuka Pharmaceutical Factory, Inc.

Nisshinbo Industries, Inc.

Eiji Sakashita

Hiroshi Kamogawa

Takashi Komai

Fujio Inoue

Soichiro Takenishi

Motoki Yonekawa

Kazuo Hino

Kaneji Asakawa

Keiichi Miyashita

Tetsuya Tachikawa

Akio Kawamura

Kiyotoshi Sekiguchi

Akio Kawakura

Sadahito Shin

Ryoichi Umemoto

Hisanobu Hirano

This invention provides a selective cellular fibronectin (cFN) adsorbent utilizing a nonwoven cellulose sulfate fabric and a method for fractional purification of FN which-comprises contacting an FN matter containing both plasma fibronectin (pFN) and cellular fibronectin (cFN) with the nonwoven cellulose sulfate fabric to separate pFN and cFN from each other. By the fractional purification method of the invention, cFN and pFN can be fractionated in an expedient manner and with high efficiency and both pFN and cFN can be recovered in high purity and good yield.

Adsorbent for cellular fibronectin, a method for fractional purification

The invention provides an anti-EDA monoclonal antibody which recognizes an amino acid sequence portion in the EDA region of fibronectin (FN). The antibody of the invention has specific reactivity against EDA, in particular EDA-FN. By utilizing it, a simple and easy, high-sensitivity and high-precision immunoassay method for EDA-FN as well as a screening or diagnostic technique for EDA-FN-associated inflammatory and other diseases can be established.

Anti-EDA monoclonal antibody and a method for diagnosis of disease

In a process for filtering plasma by separating blood into blood cells and plasma by a primary filter and filtering the separated plasma by a secondary filter to remove macromolecules from the plasma as harmful components, the loss of plasma to be discarded from the system by a procedure for eliminating plugging of the secondary filter can be diminished by opening an inner chamber of the secondary filter to the atmosphere to thereby lower the internal pressure of the chamber every time increase of the pressure to an upper limit value due to an increasing plugging tendency of the secondary filter is detected, and washing the interior of the secondary filter from the inner and outer chamber sides after the internal pressure has lowered.

Apparatus for filtering plasma

Adsorbent for cellular fibronectin and a method for fractional

Process for filtering plasma and regenerating a secondary filter therefor

Growing community of inventors

Tokushima, Japan

Eiji Sakashita