Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Eiji Ogino

Nobutaka Tani

Michio Nomura

Takashi Asahi

Fumiyasu Hirai

Takehiro Nishimoto

Shigeo Furuyoshi

Hidekazu Miyauchi

Mariko Matsumoto

Chihiro Koga

Shuichi Kaneko

Kohei Fukaya

Akito Sakai

Souichi Morikawa

Kazuo Suzuki

Osamu Odawara

Kazumasa Ohara

Takamune Yasuda

Takahisa Nakai

Hiroyuki Maruyama

Sakiko Hanita

Ai Yonezawa

Takayuki Sakogawa

A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen; and a connection member that connects the other ends of the tubular members. A base end part including the other end of at least one of the tubular members is tapered down toward the connection member and the base end part has an inlet/outlet port communicating with the lumen of the tubular member. A portion of the base end part constituting peripheral edge of the inlet/outlet port and the connection member are connected together.

Lacrimal duct tube

A lacrimal duct tube includes: a pair of tubular members that each have at one end an opening communicating with a lumen and have in a wall a hole for guiding a lacrimal duct tube operative instrument to the lumen; and a connection member that connects the other ends of the tubular members. Surfaces of the tubular members include a hydrophilic-coated portion and a non-coated portion without the hydrophilic coating. It is preferred that the lumen in the vicinity of the opening includes an engagement portion for engagement with a tip of the lacrimal duct tube operative instrument, and the non-coated portion is formed without overlapping with the surface of the tubular member at the position of the engagement portion. The lacrimal duct tube can be used favorably for various lacrimal duct obstruction treatments. In the case of using a sheath such as in sheath guided endoscopic probing, the lacrimal duct tube can be easily inserted into the sheath and be firmly fixed to the sheath. In the case of inserting the lacrimal duct tube directly into the lacrimal duct, the lacrimal duct tube can be easily passed through the lacrimal duct and be easily operated in the lacrimal duct.

The present invention provides a lacrimal duct tube that can be preferably used for the treatment of lacrimal duct obstruction, in particular, sheath guided endoscopic probing having been frequently performed in recent years, the lacrimal duct tube being excellent in passage through a lesion in the lacrimal duct, operability in the lacrimal duct, and manipulation of the endoscope inserted into the lumen of the tube, and providing a sufficient viewing field of the endoscope. The present invention relates to a lacrimal duct tube, including: a pair of tubular members that each has an opening at one end and a hole in a side wall communicating with a lumen; and a connection member that connects other ends of the tubular members, wherein the tubular members each include a plurality of resin portions different in Shore hardness, at least one of the resin portions is positioned between the opening and the hole and forms a lumen wall of the tubular member, and the lumen wall has a Shore hardness of 57D or more.

The present invention provides a peptide which selectively adsorbs an anti-&#x3b2;1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-&#x3b2;1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-&#x3b2;1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-&#x3b2;1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.

Adsorbent adsorbing antibody against &#x3b2;1 adrenoreceptor

The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber. The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.

Peptide capable of binding to insulin-binding protein and adsorbent

An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against &#x3b2;1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.

Adsorbents for dilated cardiomyopathy

The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Peptide, novel adsorbent, adsorption unit and adsorption method

An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.

Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method

An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.

Method for removing toxic shock syndrome toxin-1 in body fluids by adsorption

Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S&mdash;S bonds. This improves immobilization efficiency and suppresses deterioration of inherent characteristics of the SH group-containing compound. Antioxidants include sodium pyrosulfite (sodium disulfite), sodium sulfite, sodium hydrogensulfite, sodium hydrosulfite and L-ascorbic acid. SH group-containing compounds include cysteine, peptides or proteins containing cysteine and thiol compounds such as ethanethiol, aminoethanethiol, benzylthiol and thiophenol. Preferably, the SH group-containing compound has a molecular weight not more than 3&times;10,. The support may be activated by a functional group such as glycidyl, imidocarbonato, tosyl, tresyl, carboxyl, amino, azido or hydroxyl. The support can be inorganic such as glass beads or organic such as a synthetic polymer or a polysaccharide.

Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant

Adsorbent for immunoglobulins and complexes thereof, adsorption method,

An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.

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Settsu, Japan

Eiji Ogino