Takara Shuzo Co., Inc.

Takara Bio Inc.

Other

Eiji Nishiyama

Ikunoshin Kato

Hiroaki Sagawa

Nobuto Koyama

Takanari Tominaga

Katsushige Ikai

Tatsuji Enoki

Hua-Kang Wu

Eiji Kobayashi

Hiromu Ohnogi

Michio Hagiya

Takeshi Sakai

Fu-Gong Yu

Suzu Deguchi

Jun Tomono

Hideto Chono

Akihiro Kondo

Shigetoshi Mizutani

Tuo-Ping Li

Masahiro Shiraga

Motoko Ueda

Tatsui Enoki

To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.

Fucoidan-containing cosmetics

Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

Use of algae-derived physiologically active substances for treating a carcinomatous disease

The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

Remedies

Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I):These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.

Drugs, foods or drinks with the use of algae-derived physiologically active substances

Medicinal compositions

Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula &lsqb;I&rsqb;, optically active isomers and salts thereof, wherein R and R are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

Remedies or preventives containing cyclopentenone compounds as the active ingredient

Product of heat treatment of uronic acid, food, drink, or drug including the product

An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula &lsqb;I&rsqb; and an optically active substance and a salt thereof as an effective component.

Antirheumatic agents

An antiallergic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula &lsqb;I&rsqb; and an optically active substance and a salt thereof as an effective component.

Antiallergic agents

A therapeutic or preventive agent for diabetes mellitus which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-1-one represented by the following formula &lsqb;I&rsqb; and an optically active substance and a salt thereof as an effective component.

Diabetes remedies

A compound represented by the following formula &lsqb;I&rsqb; or an optically active substance or a salt thereof.

Compounds

Cyclopentenones, process for preparing the same, and the use thereof

Growing community of inventors

Moriyama, Japan

Eiji Nishiyama