Ajinomoto Co., Ltd.

Katayama Seiyakusyo Co., Ltd.

Eiji Nakanishi

Masahiro Murata

Toshihiko Yoshimura

Nobuyasu Suzuki

Hiroyuki Izawa

Shingo Makino

Takashi Tsuji

Kazuyuki Sagi

Yuko Satake

Tatsuya Okuzumi

Akira Chiba

Yasuhiro Tanaka

Manabu Suzuki

Naohiko Yasuda

Chieko Ejima

Mitsuhiko Kojima

Takayuki Suzuki

Yuji Tanaka

Hisao Iwagami

Miho Ono

Kazuhiro Watanabe

Hideyuki Tanaka

Kunisuke Izawa

Norimasa Onishi

Toshihiro Hatanaka

Shigeru Yamanaka

Nobuo Kondo

Yasuo Irie

Yoko Masuzawa

Ikuo Kira

Yukio Nihei

Masahiko Okunishi

Yasuyuki Kurita

Sadao Hayashi

Hideomi Saito

Hiroshi Ban

Yukio Sasaki

Hidehiro Ichinose

Noriko Yasa

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin. 

Phenylalanine derivatives

Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning &#x3b1;4 integrin in which &#x3b1;4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj&#xf6;gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the &#x3b1; 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which &#x3b1; 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj&#xf6;gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, and diabetic macroangiopathy, hypertension, arteriosclerosis), hypertension, and arteriosclerosis. 

Benzene compounds

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin.

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin 

Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin 

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1; 4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1; 4 integrin.

Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to &agr;4&bgr;7 integrin and a selectivity toward &agr;4&bgr;1 integrin. They are used as therapeutic agents for various diseases to which &agr;4&bgr;7 integrin relates.

Herein disclosed are novel cephem compounds represented by the following general formula (I), and novel antimicrobial, and especially anti-MRSA, agents which contain as an active ingredient at least one of the novel cephem compounds and the physiologically acceptable salts thereof. ##STR1##

Cephem compounds and antimicrobial agents

(S)-1phenyl-1,3-propanediol or a derivative thereof having high optical purity can be produced simply in high yield, by contacting 1-phenylpropan-3-ol-1-one with a culture of microorganisms, microorganism cells isolated from the culture, or a product obtained by processing the microorganism cells.

Method of preparing (S)-1-phenyl-1,3-propanediol or derivatives thereof

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Kawasaki, Japan

Eiji Nakanishi