Osaka University

Takara Shuzo Co., Inc.

Suntory Holdings Limited

Wako Pure Chemical Industries, Inc.

Fujifilm Wako Pure Chemical Corporation

J-chemical Corporation

Eiji Miyoshi

Naoyuki Taniguchi

Yoshito Ihara

Nobuto Koyama

Yuka Kobayashi

Takashi Saito

Akihiro Kondo

Tatsuo Kurosawa

Norio Nonomura

Atsushi Nishikawa

Takatoshi Nakagawa

Kazutoshi Fujita

Ayumi Akinaga

Kayoko Kidowaki

Kimihiro Nishino

Naoya Kataoka

Shinji Takamatsu

Yoshihiro Kamada

Miyako Nakano

Norio Hayashi

Masahiko Tsujii

Shinichiro Shinzaki

Hideki Iijima

The invention provides gastroenterological cancer determination methods that involve contacting a specimen, an antibody 1 that recognizes an &#x3b1; chain of human haptoglobin, and an antibody 2 that recognizes a &#x3b2; chain of human haptoglobin and does not recognize human haptoglobin in which an S&#x2014;S bond is cleaved to form a complex 1, or contacting the specimen and two antibodies selected from the antibodies 2 that recognize a &#x3b2; chain of human haptoglobin and do not recognize human haptoglobin in which an S&#x2014;S bond is cleaved to form a complex 2. A determination is made based on the measurement of complex 1 or 2. Alternatively, the specimen and two antibodies selected from the antibodies 1 that recognize an &#x3b1; chain of human haptoglobin are contacted to form a complex 3, and a determination is made by comparing the measurement results of complex 1 or 2 with complex 3.

Detection of haptoglobin for gastrointestinal cancer determination

[Problem] To provide a method for detecting high-risk prostate cancer, for the purpose of providing useful information, such as necessity of biopsy, to a test-positive patient in a PSA test. [Solution] The method for detecting high-risk prostate cancer according to the present invention comprises reacting a PSA contained in a sample composed of urine collected from a human body which is suspected to be suffering from prostate cancer with (1) a fucose &#x3b1;1&#x2192;6 affinitive lectin which has a characteristic property that the lectin has affinity expressed by a binding constant of 1.0&#xd7;10Mor more (at 25&#xb0; C.) for an &#x3b1;1&#x2192;6 fucose sugar chain No. 405. The fucose &#x3b1;1&#x2192;6 affinitive lectin is preferably (2) a fucose &#x3b1;1&#x2192;6 specific lectin which has a characteristic property that the lectin has a binding constant of 1.0&#xd7;10Mor less (at 25&#xb0; C.) for a sugar chain No. 003 that does not contain &#x3b1;1&#x2192;6 fucose and a glycolipid-type sugar chain No. 909 that does not contain &#x3b1;1&#x2192;6 fucose.

Method, biomarker and diagnostic agent for detection of high-risk prostate cancer

The instant invention provides a method for the differential diagnosis of inflammatory bowel disease which comprises, determining the relative ratio of G0 oligosaccharide represented by formula (I): to G2 oligosaccharide represented by formula (II): wherein G represents galactose, M represents mannose, GN represents N-acetylglucosamine and F represents fucose in serum IgG oligosaccharide fraction obtained from a patient with inflammatory bowel disease or a patient with suspicion of inflammatory bowel disease, anddiscriminating inflammatory bowel disease based on the obtained ratio.

Method for determination of inflammatory bowel disease

The determination (test, diagnosis) of pancreatic cancer can be performed with high accuracy by detecting a fucosylated sugar chain (N-glycan) present in a specific site of the human haptoglobin and using an amount of the fucosylated sugar chain as a tumor marker for pancreatic cancer.

Tumor marker for pancreatic cancer and method of testing the same

The present invention provides a peptide or protein having a neovascularization action and containing a basic amino acid cluster region of &#x3b2;1,6-N-acetylglucosaminyltransferase, a neovascularization accelerator containing the above-mentioned peptide or protein, a method of screening an inhibition substance for the above-mentioned peptide or protein, and a neovascularization inhibitor containing this inhibition substance.

Glycosyltransferase GnT-V having neovascularization action

Inhibitor for viral replication

An isolated DNA having a promoter activity in an animal cell; a method for expressing a useful gene using the isolated DNA; and a method for producing a protein in an animal cell using the isolated DNA. The present invention provides a method for producing a desired gene product in a large quantity in an animal cell.

Promoter and method of gene expression using the same

Growing community of inventors

Suita, Japan

Eiji Miyoshi