Astellas Pharma Gmbh

Kotobuki Pharmaceutical Co Ltd

Kotobuki Pharmaceuticals Co., Ltd.

Eiji Kurosaki

Takeshi Murakami

Yoshinori Kobayashi

Atsushi Noda

Hiroshi Tomiyama

Kazuhiro Ikegai

Masakazu Imamura

Kayoko Kitta

Takashi Sugane

Ryota Shiraki

Fumiyoshi Iwasaki

Takayuki Suzuki

Noriaki Maeda

Ryota Astellas Pharma Inc Shiraki

The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via &#x2014;X&#x2014; and A ring is directly bonded to the glucose residue, and it is usable as a Na-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

C-glycoside derivatives and salts thereof

The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue, and it is usable as a Na-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes-related diseases such as insulin-resistant diseases and obesity.

Azulene derivatives and salts thereof

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Tokyo, Japan

Eiji Kurosaki