Asahi Kasei Kogyo Kabushiki Kaisha

Eiji Kodama

Joji Nishikido

Mitsuru Shibukawa

Chisei Shibuya

Novel cephalosporin compounds having antibacterial activity, which are represented by the following compounds of the general formula (I), ##STR1## wherein R.sub.1 represents an amino group or a protected amino group;

Cephalosporin compounds

A cephalosporin compound of the general formula (I): ##STR1## wherein X is a hydrogen atom, a chlorine atom, a methyl group, a methoxy group, an acetoxymethyl group or --CH.sub.2 SHet wherein Het is a 5- or 6-membered heterocyclic ring containing therein 1 to 4 nitrogen, oxygen or sulfur atoms;

Cephalosporin compound

A method for improving the intestinal absorption of a cephalosporin derivative by bonding an oligopeptide having the general formula (I): ##STR1## wherein X is a hydrogen atom, C.sub.1-15 alkyl group, R.sub.3 CO-- group wherein R.sub.3 is a hydrogen atom or straight or branched chain C.sub.1-15 alkyl group or a protective group easily removable by acid hydrolysis, hydrogenolysis or enzyme existing in a living body;

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Eiji Kodama