Takara Bio Inc.

Takara Shuzo Co., Inc.

Hitachi, Ltd.

Otsuka Pharmaceutical Factory, Inc.

Hitachi Information & Control Solutions, Ltd.

Nec Corporation

Jichi Medical University

Sysmex Corporation

Tokyo Medical and Dental University

Hitachi Industry & Control Solutions, Ltd.

Tokyo Women's Medical University

The Jikei University

Bios Co., Ltd

Eiji Kobayashi

Ikunoshin Kato

Hiroaki Sagawa

Nobuto Koyama

Katsushige Ikai

Tatsuji Enoki

Shin Kokura

Hiromu Ohnogi

Eiji Nishiyama

Satoru Funaki

Akihiro Onozuka

Masakazu Ishikawa

Tamaki Wada

Masako Doi

Naoya Mashiko

Takashi Uemori

Hiroyuki Mukai

Masahiro Shiraishi

Hua-Kang Wu

Masamitsu Kobayashi

Takashi Umehara

Yasuyuki Furuta

Suzu Deguchi

Akira Bando

Wataru Sasaki

Yusuke Seki

Yasuhiro Kiyofuji

Yusaku Otsuka

Yoshimi Sato

Takanari Tominaga

Toshiki Shimizu

Takashi Yokoo

Toshiyuki Sato

Yuki Aihara

Akihiro Ohashi

Tatsuyuki Ootani

Yu Iwasaki

Tuo-Ping Li

Akihiro Nakano

Shoichi Ozawa

Yuta Sugimoto

Akira Bandou

Yuusuke Seki

Tsutomu Yamada

Satoshi Nakamura

Kiyozo Asada

Norihiro Yoshinaga

Yasuhiro Fujimoto

Noritaka Matsumoto

Hiromichi Endoh

Jun Tomono

Tetsuo Shiba

Masaya Okada

Masashi Suenaga

Katsumi Yoshida

Junko Yamamoto

Nobuyasu Hori

Akihiro Kondo

Kazue Miyake

Kenji Akama

Kazumi Hakamada

Mitsuko Ideno

Takeshi Kikuchi

Hideaki Masuko

Hiroshi Nagashima

Michio Hagiya

Masaki Shibayama

Osamu Takeda

Fuyuko Takashima

Nobuko Muraki

Takahiro Marui

Shigetoshi Mizutani

Kaoru Inami

Hitomi Matsunari

Yasutaka Fujita

Hisao Nagayama

Ichiro Sekiya

Katsumi Sugiyama

Masahiro Shiraga

Kinuko Nagamine

Akiko Kato

Atsushi Nishioka

Masakazu Kadowaki

Fumihiko Nemoto

Takenori Kasahara

Yukiko Tahara

Yuki Ueda

Mariko Moriyama

Haruhisa Sawaragi

Yoko Tatsumi

Motoko Ueda

Satoshi Yanagi

Takumi Teratani

Koutaro Kai

Ryo Fujita

Tatsuyuki Otani

Hideyuki Yoshikawa

Takao Imazawa

A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.

Cell area determination method, cell imaging system, and cell image processing apparatus

An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.

Organ for transplantation and organ structure

A mammalian cell suspension prevents pulmonary embolism formation during administration of mammalian cells, such as mammalian stem cells, through a blood vessel, and a preventive agent against pulmonary embolism formation during administration of mammalian cells through a blood vessel. suspending mammalian cells, such as mammalian stem cells, are suspended in a physiological aqueous solution containing trehalose or its derivative, or a salt thereof as an active ingredient to prepare a mammalian cell suspension for preventing pulmonary embolism formation during administration of the mammalian cells through a blood vessel, including the mammalian cells and trehalose or its derivative, or a salt thereof as active ingredients. Examples of the mammalian cells can include pancreatic islet cells, dendritic cells, natural killer cells, alpha/beta T cells, gamma/delta T cells, and cytotoxic T lymphocytes in addition to mammalian stem cells. Preferred mammalian stem cells can include mammalian mesenchymal stem cells and mammalian pluripotent stem cells.

Trehalose-containing mammalian cell suspension for prevention of pulmonary embolism formation

Disclosed is a method for obtaining differentiated cells and/or differentiated cell products, including the steps of: introducing undifferentiated cells into a perfused organ or living tissue; subjecting the undifferentiated cells introduced to perfusion culture together with the organ or living tissue so as to allow the undifferentiated cells to differentiate, thereby obtaining differentiated cells and/or differentiated cell products; collecting a perfusion culture solution that contains the resulting differentiated cells and/or differentiated cell products; and obtaining the differentiated cells and/or differentiated cell products contained in the collected perfusion culture solution.

Method for obtaining differentiated cells and/or differentiated cell products from undifferentiated cell and a method of perfusion culture

The present invention provides a mammalian stem cell suspension containing mammalian stem cells and at least one polysaccharide such as trehalose, and the like; a mammalian stem cell aggregation inhibitor containing polysaccharide such as trehalose, and the like; a method of suppressing aggregation of mammalian stem cells, containing suspending the mammalian stem cells in an aqueous physiological solution containing polysaccharide; an inhibitor of a decrease in the survival rate of mammalian stem cells containing polysaccharide such as trehalose and the like; a method of suppressing a decrease in the survival rate of mammalian stem cells, containing suspending the mammalian stem cells in an aqueous physiological solution containing polysaccharides, and the like.

Stem cell suspension

The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof.

Artificial kidney precursor and process for production thereof

Methods of washing adherent cells, capable of effectively suppressing cell death due to proteolytic enzyme treatment for detaching the adherent cell from a culture vessel and subsequent cell treatment; cell-washing solutions used for the washing method; methods of producing cell suspensions for transplantation using the cell-washing solution; and kits comprising the cell-washing solution. Trehalose or its derivative or a salt thereof is added to physiological aqueous solutions to prepare cell-washing solutions containing trehalose or its derivative or a salt thereof as an active ingredient. The cell-washing solutions can be used to wash adherent cells before detaching the adherent cells from a culture vessel by proteolytic enzyme treatment to suppress cell death due to the proteolytic enzyme treatment. The concentration of trehalose applied to the cell-washing solution may be a concentration capable of suppressing the cell death due to the proteolytic enzyme treatment, such as 0.1 to 20 (w/v) %.

Method of washing adherent cell using trehalose-containing cell-washing solution

The present invention provides a duplexed operation processor control system that includes operation processors, an I/O device, and at least one communication path that couples the operation processors to the I/O device, and at least one communication path that couples the operation processors with each other. The duplexed operation processor control system switches over either of the operation processors to be a primary operation processor that executes a control operation for a control target, and the other to be a secondary operation processor that is in a stand-by state, and the secondary operation processor snoops control data synchronously when the primary operation processor acquires the control data from the control target.

Duplexed operation processor control system, and duplexed operation processor control method

A method for accurately and easily detecting a synthetic siRNA, for example, a siRNA in which the 3' end is DNA, and a kit used for the method are provided. The present invention relates to a method for detecting a siRNA in which the 3&#x2032; end is DNA, comprising: (a) adding polydeoxyadenosine to the 3&#x2032; DNA end of at least one strand of the siRNA to be detected to produce a polydeoxyadenosine-added RNA; (b) annealing a polydeoxythymidine primer having a tag sequence at its 5&#x2032; side to the polydeoxyadenosine-added RNA and synthesizing DNA from the primer by a reverse transcription; and (c) detecting the DNA synthesized in (b).

Synthetic siRNA detection method

The present invention provides a method for evaluating preservative effect of a tissue preservation solution, comprising immersing a mammalian tissue introduced with a luminescence or fluorescence labeling gene in the tissue preservation solution, measuring a luminescence or fluorescence level by the labeling gene in the tissue after immersion, and evaluating the preservative effect of the tissue preservation solution based on the luminescence or fluorescence level.

Method for evaluation of tissue preservation solution

A multi unit controller has a plurality of base units each of which includes a control unit connector, a base unit connector through which the base units juxtaposed to each other are connected to each other, and a plurality of control units connected to the base units respectively through the respective control unit connector, wherein the base units juxtaposed vertically.

Multi unit controller

A processing unit is connected to another processing unit through a system bus composed of serial signal communication line and synchronization signal communication line to be able to communicate therewith. When an operation unit detects abnormal state in the processing unit, the operation unit supplies notification of detection of the abnormal state to synchronization unit. The synchronization unit transmits the received detection notification of abnormal state to the other processing unit through the synchronization signal communication line. Conversion unit receives parallel communication data from the operation unit through important signal line instead of general signal line and converts the received parallel signal into serial signal to be transmitted to the other processing unit through the serial signal communication line, thereby soundness among processing units connected to the system bus is ensured when the system bus is configured to attain serial communication.

Processing unit, process control system and control method

In a control apparatus which transmits/receives data from a central processing unit via a serial transfer channel to a communication control unit, and groups/distributes data of input/output units from the communication control unit via a parallel transfer channel, the control apparatus initiates a diagnosing unit of the parallel transfer channel in response to an instruction issued from the central processing unit, and diagnosis the input/output units subsequent to the diagnosis of the transmission channel. Data input/output timing of the input/output unit is also instructed from the central processing unit, so that the central processing unit can suppress lowering of response speeds caused by the diagnoses, and can maintain the periodicity of the data input/output.

Control apparatus, control method and control program

A failure is detected immediately and certainly, and continuation of processing in an unstable state is prevented. A first error detection code is generated from first information which is output as a result of execution of a predetermined program conducted by a first processor. A second error detection code is generated from second information which is output as a result of execution of the program conducted by a second processor which is configured so as to output the same computation result as that of the first processor. It is detected whether the first information is the same as the second information, and it is detected whether the first error detection code is the same as the second error detection code. Writing the first information or the second information into a main memory is controlled on the basis of a result of the detection.

Control apparatus and control method

Growing community of inventors

Wakayama, Japan

Eiji Kobayashi