Nsk Corporation

Isuzu Motors Limited

Eisai R&d Management Co., Ltd.

Kawasaki Jukogyo Kabushiki Kaisha

Mitsubishi Corporation

Other

Fujifilm Business Innovation Corp.

Kawasaki Steel Corporation

Kawasaki Jukogyo Kabushiki Kaisha Mitsubishi Corporation

Volkswagen Ag

Eiji Inoue

Takashi Imanishi

Yoshio Uchiyama

Junya Nakatani

Hiroki Nishii

Takumi Shinojima

Toshio Imai

Hiroyasu Yoshioka

Kouji Ishikawa

Yasuyuki Matsuda

Shinji Miyata

Nagao Dohi

Atsushi Yamazaki

Kazutaka Tanaka

Hiroshi Kato

Akihiro Yamamoto

Tomohiro Inoue

Norihisa Kobayashi

Hirohisa Tanaka

Hideyuki Imai

Yuji Shimomura

Kenichiro Tanaka

Daisuke Gunji

Kippei Matsuda

Yuichi Ono

Jörg Möckel

Yuya Daikoku

Hideo Kaneko

Kenji Komatsu

Hidetaka Koga

Rainer Petersen

Peter Tenberge

Torakatsu Miyashita

Teruyuki Nakazawa

Toshiro Toyoda

Takumi Sinojima

Akio Nio

Akio Yamada

Aki Nakatani

Satoru Iijima

Toshihisa Ohtsuka

Etsuko Rikitsu

Marie Inoue

Tomomi Kawakatsu

Maki Deguchi

Hirotaka Kishida

Toshirou Toyoda

Masahiro Kita

Shin Yamamoto

Tsutomu Hibi

Shunsuke Ito

Takefumi Okamoto

Shoichi Hiwasa

Takashi Obara

Armin Sue

Satoshi Satoh

Akira Murata

Toshihiko Sato

Daiki Shirota

Toshifumi Hirayama

Satoshi Kishi

Shinji Shiraishi

Maki Tawarada

Aki Togawa

Emiko Kamakura

Keiko Watanabe

Hideaki Hirata

Isamu Ishii

Ryota Taguchi

Atsushi Yanazaki

An output shaft is configured by connecting a first shaft and a second shaft, coaxially arranged with each other, by a reverse input cutoff clutch 20; an end portion on one side in an axial direction of the second shaft located on an opposite side from the first shaft with a gear portion sandwiched in between in the axial direction being rotatably supported with respect to a fixed portion by a bearing device; the reverse input cutoff clutch having a function that, when rotational torque is input to the first shaft, transmits the rotational torque input to the first shaft to the second shaft, and when rotational torque is reversely input to the second shaft, completely cuts off the rotational torque reversely input to the second shaft and does not transmit the rotational torque to the first shaft, or transmits part of the rotational torque to the first shaft and cuts off the remaining portion.

Electric motor with reverse input cutoff clutch

A differential device includes: an input member; a case member arranged coaxially with the input member; a one-way clutch arranged between the input member and the case member and transmitting torque therebetween only when the input member attempts to rotate in a normal rotation direction; a pinion gear supported by the case member to rotate about the axis perpendicular to the center axis of the case member; and a pair of side gears supported coaxially with the input member to rotate relative to the input member and the case member and meshing with the pinion gear.

Differential device

The rotation transmission state switching device comprises a clutch device comprising a first rotating member having a first-rotating-member-side engaging portion, a second rotating member having a second-rotating-member-side engaging portion, a third rotating member having a third-rotating-member-side engaging portion; and an engaging element having an engaging-element-side first engaging portion engaging with the first-rotating-member-side engaging portion, an engaging-element-side second engaging portion engaging with the second-rotating-member-side engaging portion, and an engaging-element-side third engaging portion engaging with the third-rotating-member-side engaging portion; and a restriction device configured to switch between allowing and restricting rotation of the first rotating member, allowing or preventing torque transmission between the second rotating member and the third rotating member.

Rotation transmission state switching device

A 3D model evaluation system includes: a loading unit that loads 3D model data created by 3D CAD; a history checking unit that checks a creation history which is added to the 3D model data loaded by the loading unit and which is obtained in a case where the 3D model data is created by the 3D CAD; and an evaluation unit that evaluates a degree of coincidence between the creation history of the 3D model data checked by the history checking unit and a predetermined rule.

3D model evaluation system

Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.

Anti-EphA4 antibody

A toroidal continuously variable transmission includes a preload spring disposed between a rotary assembly including a first disc and a pressing device, and a driving force transmission shaft, and a thrust bearing disposed between a first member and the preload spring, the first member being one of the rotary assembly and the driving force transmission shaft. In a direction of an axis line, a gap is formed between a second member and the thrust bearing, the second member being the other of the rotary assembly and the driving force transmission shaft. A dimension of the gap in the direction of the axis line is less than a deformation amount of the preload spring in the direction of the axis line, at an elastic limit.

Toroidal continuously variable transmission

It is intended to provide an anti-EphA4 antibody or an EphA4-binding fragment thereof which is capable of binding to EphA4 and inhibiting the binding between EphA4 and its ligand, and a pharmaceutical composition comprising the anti-EphA4 antibody or the EphA4-binding fragment thereof as an active ingredient. A mouse anti-EphA4 antibody having binding affinity for EphA4 was obtained, and the sequences of complementarity-determining regions (CDRs) of the mouse anti-EphA4 antibody were identified. This allowed for preparation of a humanized antibody comprising the CDR sequences of the mouse anti-EphA4 antibody in heavy chain variable region and light chain variable region.

Projections protruding towards a cam plate and a disc are provided on both axial side surfaces of the retainer at a plurality of positions at which phases of the projections in the circumferential direction are offset from pockets. One axial direction surface of the cam plate and the disc are formed with concave portions at portions facing the respective projections. The concave portions have an axial depth deepest at a center portion thereof in the circumferential direction and becoming shallower towards both end portions thereof.

Loading cam device and friction roller-type speed reducer

A method for detecting a neurological disease associated with cognitive impairment, wherein the extracellular domain of EphA4 is measured from a biological sample taken from a subject.

Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain

Construction of a friction roller reducer is achieved wherein displacement of intermediate rollers due to the change in thickness in the axial direction of loading cam apparatuses can be performed smoothly, and excellent transmission efficiency can be obtained. Long guide holes that are long in the radial direction of a sun roller and ring-shaped roller are provided in guide blocks that are fastened to a support frame for supporting the end sections of rotation shafts of intermediate rollers. The outer rings of ball bearings, of which the inner rings are fitted around and fastened to the outside of the end sections of the rotation shafts, engage with the long guide holes so as to be able to displace in the radial direction of the sun roller and the ring-shaped roller.

Friction roller reducer and drive unit for electric automobile

Construction capable of improving the convenience of an electric automobile is achieved by making the drive apparatus for an electric automobile in which a planetary-gear transmissionis assembled more compact and simple, and increasing the distance traveled per charge. The planetary-gear transmissioncomprises a single-pinion first planetary-gear mechanismand a double-pinion second planetary-gear mechanism, and reduces power from an electric motorby a desired reduction ratio before transmitting that power to a driven-side rotating shaft. A first braking deviceswitches a ring gearand a second braking deviceswitches a second sun gearbetween a state of being allowed to rotate and a state of being prevented from rotating with respect to a fixed portion.

Drive apparatus for an electric automobile

A toroidal continuously variable transmission of the present invention comprises: input side disks () and output side disks () being supported concentric with each other such that the disks can rotate freely; a trunnion () that comprises end sections () on both ends on which tilt shafts () that are concentric with each other are provided, and a support beam section () that extends between both end sections (), the trunnion () being capable of pivotally displacing around the tilt shafts (); a thrust rolling bearing (); and a power roller () that is supported to the inside surface of the trunnion () by way of the thrust rolling bearing () such that it rotates freely; wherein the support beam section () comprises an inside surface having a cylindrical convex surface (); the thrust rolling bearing () comprises an outer race () having an outside surface with a concave section () that fits with the cylindrical convex surface () of the support beam section (), and a plurality of rolling bodies () that are located between the power roller () and a track of an outer race (); and the concave section () of the outer race () has side surface sections () on both sides in the width direction, fits with the cylindrical convex surface () by the cylindrical convex surface () coming in contact with both side surface sections ().

The object of the present invention is to provide a method for screening a substance that affects gelatinase-mediated EphA4 processing. The present invention provides a method for screening a substance that affects gelatinase-mediated EphA4 processing, which comprises the steps of: (a) allowing a first biological composition containing gelatinase or a biologically active fragment thereof to be contacted with a second biological composition containing EphA4 in the presence and absence of a candidate substance; (b) measuring the presence or amount of the EphA4 ectodomain and/or endodomain fragment; and (c) selecting the candidate substance as a substance that affects gelatinase-mediated EphA4 processing if the results of the step (b) measured in the presence of the candidate substance are changed in comparison with the results of the step (b) measured in the absence of the candidate substance.

Screening method using gelatinase-mediated EphA4 cleavage reaction as an indicator

The present invention provides a method of screening for compounds which affect the cleavage of EphA7 by &#x3b3;-secretase. The method includes the following steps:

Method of screening for compounds which affect the cleavage of EphA7 by&#x3b3;-secretase

Growing community of inventors

Kanagawa, Japan

Eiji Inoue