Takeda Chemical Industries, Inc.

Eiji Higashide

Mitsuko Asai

Seiichi Tanida

Satoshi Horii

Masayuki Muroi

Toru Hasegawa

Hiroshi Fukase

Kazunori Hatano

Novel peptide B-52653 having the formula: ##STR1## which is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing B-52653 in a culture medium, whereby B-52653 is elaborated and accumulated in the cultured broth and is recovered. B-52653 is useful as a germicide or disinfectant, and a possibility of the present substance as an antifibrotic agent is suggested.

Antimicrobial peptide

Streptomyces albulus subsp. ochragerus subsp. nov. culture for making

The peptide compound represented by the formula: ##STR1## which is useful as a germicide or disinfectant, is produced by reducing a compound of the formula: ##STR2## wherein Y is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group; and subjecting the reduction product compound to deprotection reaction when required. A compound of the formula: ##STR3## wherein Z is amino group which may optionally be protected; R.sup.1 is hydrogen or protective group; and R.sup.2 is hydrogen or protective group, is a useful as intermediate for production of the first-mentioned compound.

Alanyl-2-(5-hydroxy-2-oxo-pyrrolidin-3-yl)glycine

Method for production of peptide, and its intermediate

A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 is a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium and recovering the same antibiotic. Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.

Culture of Nocardia ATCC 31309

A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.

Process for preparing maytansinol

Antibiotic

The present invention relates to a substantially pure culture of the microorganism belonging to the genus Nocardia, which microorganism is capable of producing in a culture medium containing assimilable carbon and digestible nitrogen sources, a recoverable amount of the Antibiotic C-14919 E-1 or E-2 or mixtures thereof having the characteristics described in the specification. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.

Biologically pure culture of the microorganism Nocardia ATCC31280

A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 in a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium, and recovering the same antibiotic. Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.

Antibiotic C-14482 A.sub.1 and method for producing same

Novel antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 in a culture medium, whereby Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 are elaborated and accumulated in the cultured broth and are recovered. Antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are useful as a germicide or disinfectant, respectively.

Antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3

The present invention relates to a method of producing the antibiotics C-14919 E-1 and/or E-2 by cultivating an antibiotic C-14919 E-1 and/or E-2 producing strain of the genus Nocardia in a culture medium and accumulating said antibiotics. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.

Antibiotics produced from the microorganism nocardia

A novel Antibiotic C-15003 P-4 is specifically produced by cultivating a microorganism of the genus Nocardia in a culture medium containing leucine and/or its derivatives. The Antibiotic C-15003 P-4 is useful as an antifungal agent, antiprotozoan agent and antitumor agent.

Method for producing antibiotic C-15003 P-4

A novel Antibiotic C-15003 P-3 is specifically produced by cultivating a microorganism of the genus Nocardia in a culture medium containing valine or isobutyric acid and/or their derivatives. The Antibiotic C-15003 P-3 is useful as an antifungal, antiprotozoan and antitumor agent.

Method for producing antibiotic C-15003 P-3

Maytansinol esters

The present invention relates to antibiotics C-14919 E-1 and E-2 produced by cultivating a microorganism of the genus Nocardia. These antibiotics display a wide activity against e.g. Gram-positive bacteria, fungi and yeast and are useful as germicides or disinfectants.

Growing community of inventors

Takarazuka, Japan

Eiji Higashide