Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Alcon Laboratories, Inc.

Eiji Hayakawa

Kunio Ito

Kiyoshi Morimoto

Yasushi Watanabe

Sanji Tokuno

Motohiro Ohta

Tokuyuki Kuroda

Yasuhiro Ishikawa

Masashi Nakakura

Shigemitsu Miura

Makoto Kigoshi

Tomoaki Masada

Yasuhiko Ueno

Junichi Miyabe

Yuji Iwase

Hiroyuki Morimoto

John M Yanni

Shunji Ichikawa

Stella M Robertson

Katsuichi Shuto

Kuniaki Sakato

Yoichiro Yotsuya

Yuji Ueno

Akihiro Uchida

Toshiyuki Oota

Tomohiko Goto

Kazuki Asanome

Toshiro Ochiai

Noboru Aoki

Kazutoshi Kuroda

Mitsuru Terajima

Hirotake Naganuma

An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 &#x3bc;m, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

Intrabuccally rapidly disintegrating tablet and a production method of the tablets

Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 &#x3bc;m; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 &#x3bc;m and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

Microcrystal

According to the tablet production method of the present invention, tablet is produced by compressing molding material by means of punches and dies comprising the steps of using powdered or granular material including compound which is denaturalized or inactivated when tabletted at high pressure is used as the molding material, housing the punches and the dies in a spraying chamber, generating pulsating vibration air and spraying lubricant mixed in air in the spraying chamber, applying the lubricant on the surfaces of the punches and the dies while the lubricant sprayed in the spraying chamber is mixed with the pulsating vibration air, and tabletting the molding material by means of the punches applied with the lubricant on the surface thereof and the dies applied with the lubricant on the surface thereof.

Tablet manufacturing method and tablet

A press-through pack and a sealing sheet for use in the same capable of easily taking out solid material such as tablet or the like contained storage recesses by only pushing action of fingers. The pack comprises an accommodation body ( ) with plural storage recesses ( ) defined by sheet like portions ( ) for a containing solid material therein and sealing sheet ( ). The sealing sheet ( ) is made of such material that a recess ( ) in which solid material (T) contained, is partly ruptured without causing floating and peeling at the adhesion portion of the adhesive layer ( ) and the sheet like portions ( ) when pushing the projecting portion ( ) of the outer side of the recess ( ) with fingers, whereby the solid material (T) contained in the recess ( ) is easily taken out and the sealing sheet is partially bonded to the accommodation body at sheet like portions ( ) in a manner that the whole parts of sealing sheet ( ) is easily peeled off from the accommodation body.

Press-through pack, sealing sheet for press-through pack, and preparation method of tablet

A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied

Process for the production of tablets and tablets

A dividable tablet is not chipped, can be divided easily and accurately, has excellent impact resistance and rarely causes twining in the film-coating step, wherein a dividing line is formed along a center line on the upper surface of the tablet, ridgelines are each located on an inner side of the peripheral portion of the tablet to surround the dividing line in two areas defined by the dividing line on the upper surface of the tablet, the lower surface of the tablet gradually rises from the peripheral portion of the tablet toward the center portion thereof, and areas around the ridgelines are each formed by a convex surface.

Dividable tablet and press-through pack

The present invention provides a tablet containing isotope-labeled urea and an inorganic compound.

Isotopic urea tablets

The present invention relates to a solid dispersion and a solid dispersion dosage form which comprise a xanthine derivative represented by the following formula (I) or a pharmacologically allowable salt thereof and a polymer.

Solid dispersion dosage form of amorphous xanthine derivative and enteric-coating polymer

Method for stabilizing compound DX-52-1 and lyophilized composition

Method for stabilizing duocarmycin derivatives

Topical ophthalmic formulations of the invention contain as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof. The formulations are useful for treating allergic eye diseases such as allergic conjunctivitis, vernal conjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis.

Topical ophthalmic formulations for treating allergic eye diseases

A motilin preparation in the form of a rectal suppository containing motilin together with a pH controller capable of adjusting the pH value of the intrarectal fluid to 8.0 to 10.0, which is highly useful as a rectal suppository.

Rectal motilin preparation

Growing community of inventors

Shizuoka, Japan

Eiji Hayakawa