Japanese Foundation for Cancer Research

Ishizaki Co., Ltd.

Mitsubishi Denki Kabushiki Kaisha

Eiji Hara

Nobuyuki Ishizaki

Takeshi Ouchi

Naoko Ohtani

Tze Mun Loo

Shin Yoshimoto

Daisuke Kikuchi

Junji Kobayashi

Hiroshi Kurokawa

Yusuke Yoshida

Satoru Toyama

Futoshi Hasegawa

Kazuhiko Kojima

Kazuhiro Ota

Jiro Naka

Noriko Hirano

The check valve includes: an inlet pipe body part () which includes an inflow port (); an outlet pipe body part () which includes an outflow port (); a mobile body (a reciprocative body ()). Insides of the inlet pipe body part, the outlet pipe body part, and the valve body () are communicated to form a curved flow path from the inflow port toward the outflow port. The reciprocative body includes a valve element (). The seat () is arranged so as to be capable of supporting the valve element and the inflow port and the seat are arranged parallel to each other. An inner wall surface () on an outside-corner side of the flow path in the inlet pipe body part is formed so as to curve toward a side of the outlet pipe body part as a position gets closer from the inflow port to the seat.

Check valve

The check valve () is of straight pipe joint type and oblique lift type. It includes: a valve seat (); a moving body () capable of linearly reciprocating between a closed state where it is in close contact with the valve seat and an open state where it is separated from the valve seat; a primary flow path (inflow path ()) on an upstream side of the moving body; and a secondary flow path (outflow path ()) on a downstream side of the moving body. The moving body includes a valve body () and a valve shaft () extending from the valve body. The valve seat supporting the valve body is formed to straddle the center line (CL) of the connection flow path that linearly extends including the primary flow path (inflow path) and the secondary flow path (outflow path) in a cross section including the center line thereon.

The present invention provides a method for screening for a food ingredient or a food composition that reduces a cancer risk and inhibits cancer development. A substance that reduces a cancer risk is screened by administering a candidate substance and analyzing alteration in gut microbiota or a metabolite produced by an intestinal bacterium. Also, candidate substances are screened by adding each candidate substance to a bacterial culture system and analyzing its effect on a bacterium involved in cancer development.

Method for screening food ingredients and food compositions

The present invention provides a method capable of detecting a cancer and/or a carcinogenic risk, and a reagent for the detection thereof. The present invention also provides a method for screening for a pharmaceutical drug for reducing a carcinogenic risk and a pharmaceutical composition. Since cancer development closely correlates with alteration in gut microbiota, cancer development and/or a risk of cancer development are detected by detecting alteration in gut microbiota and a secondary bile acid produced by an intestinal bacterium. The present invention further provides a method for screening for a pharmaceutical drug with a gut microbiota as an index, and a pharmaceutical composition.

Method for examination of carcinogenic risk

A method for analyzing a minute quantity of a material included in a different material is performed in short extraction treatment without taking a long time and the minute content is rapidly analyzed. The method of analyzing a minute content includes mounting on a sample table a sample piece of a material having a minute content of a different material to be analyzed; dropping onto the sample table a solvent for extracting the minute content from the sample piece, so that the solvent is disposed between the sample table and the sample piece; maintaining at room temperature the solvent between the sample table and the sample piece, and, with the solvent maintained between the sample table and the sample piece, extracting the material of the minute content from the sample piece; and analyzing the content extracted from the sample piece.

Method of determining minute amounts of additives in polymers

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Tokyo, Japan

Eiji Hara