Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Rational Drug Design Laboratories

Eiichi Nakai

Makoto Takeuchi

Takeshi Suzuki

Hiroshi Nagata

Hiroyuki Moritomo

Sadao Kuromitsu

Shinya Nagashima

Masaki Yokota

Keiko Ohga

Hideki Kubota

Masanori Miura

Atsushi Ichikawa

Souichirou Kawazoe

Wataru Hamaguchi

Shinobu Mochizuki

Akira Toyoshima

Hiroshi Suzuki

Junji Miyata

Shunji Kageyama

Masahiro Iwata

Ryo Naito

Toru Kontani

Hiroyuki Hisamichi

Kazuhito Tanabe

Kiyoshi Yahiro

Akiko Orita

Yoji Miyazaki

Kazuhiro Nakatou

Masashiro Iwata

A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

Diaminopyrimidinecarboxamide derivative

This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.

2,4,6-Triamino-1,3,5-triazine derivative

The invention relates to a novel amide derivative which is an N-({[4-(substituted thiazol-4-yl)phenyl]carbamoyl}methyl)amide derivative having a characteristic in that an aryl or heteroaryl group as an aromatic ring group is directly substituted on the N atom of amido group. Since said amide derivative has excellent anti-herpesvirus action, it is useful as medicaments and antiviral agents, particularly as preventive or therapeutic agents for various diseases accompanied by Herpesviridae virus infections, illustratively, varicella (chickenpox) accompanied by varicella zoster virus infection, shingles accompanied by the recurrent infection of latent varicella zoster virus, labial herpes and herpes encephalitis accompanied by HSV-1 infection, genital herpes accompanied by HSV-2 and the like various herpesvirus infections.

Amide derivative

Pyrimidine-5-carboxamide derivatives

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Tsukuba, Japan

Eiichi Nakai