Chugai Seiyaku Kabushiki Kaisha

Eiichi Miyauchi

Akihiko Saito

Yasuyuki Sakai

Keiko Sano

Hidefumi Mizushima

A method for maintaining the biological activity in a protein formulation without adding an antioxidant and for inhibiting the formation of insoluble particles, comprising adding to the protein formulation a poloxamer as a surfactant.

Stabilized protein-containing formulations

An antibody-containing solution formulation comprising an organic acid and a surfactant as stabilizers; a method for suppressing the formation of visible insoluble matter and/or insoluble particles due to the presence of metal ions in an antibody-containing solution formulation, which comprises adding an organic acid to the solution; a method for suppressing the formation of visible insoluble matter and/or insoluble particles during shaking and freezing-thawing of an antibody-containing solution, which comprises adding a surfactant to the solution; and a method for stabilizing an antibody-containing solution, which comprises adding an organic acid and a surfactant.

Antibody-containing solution formulations

Protein formulations containing a poloxamer as a surfactant, and methods for maintaining the biological activity in protein formulations without adding an antioxidant and for inhibiting the formation of foreign insoluble matters by adding a poloxamer as a surfactant.

Stabilized preparation containing protein

The present invention aims to provide a lotion stably maintaining maxacalcitol and having excellent percutaneous absorption. The present invention provides lotions comprising maxacalcitol as an active ingredient and a nonionic surfactant as an additive, as well as lotions which further contains a polyhydric alcohol and a solubilizer as additives besides a nonionic surfactant.

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Tokyo, Japan

Eiichi Miyauchi