Miltenyi Biotec, Gmbh

Miltenyi Biotec B.v. Co., Kg

Miltenyi Biotec B.v. & Co. Kg

Eiad Kabaha

Stefan Miltenyi

John Stuart Foster

Martin Biehl

Winfried Schimmelpfennig

Holger Lantow

Juergen Schulz

Niklas Elmar Neuschaefer

Ralf-Peter Peters

Jürgen Schulz

Andreas Bosio

Elmar Niklas Neuschäfer

Niklas Elmar Neuschäfer

Franz Bucher

Jan Boddenberg

Nicholas C Martinez

Wolfgang Stoeters

Frederik Fritzsch

Carsten Poggel

Wolfgang Stoters

Timo Adams

Christian Peth

Juliane Stuth

Jan Keseberg

Wolfgang STÖTERS

Martin BÜSCHER

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Method for manufacturing a patient specific cell population using a multifunctional self-contained apparatus and tubing set

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (), a pump () and a plurality of valves (-) configured to at least partially control fluid flow through a fluid circuitry and a separation column () positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Devices and disposables for patient-specific cell therapy manufacturing

The invention is directed to a slide chamber comprising a top member (), a fluidic seal (), a transparent closure member () and base member () wherein the top member () is provided with at least one examination chamber () and a plurality of openings () positioned at two sides of the cover member outside of the examination chamber (); and the base member () is provided with interconnecting means () complementary to the openings () of the top member characterized in that the interconnecting means () of the base member () and the openings () of the top member () are configured to mechanically interlock with each other by lateral movement thereby pressing the top member () against the transparent closure () member in a water-tight manner.

Slide chamber

Single use tubing set for making genetically modified donor cells for reinfusion into a patient

Device and procedure for producing a cellular pharmaceutical product enriched in genetically modified target cells at the bedside or in a surgical room

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

A multilevel, disposable cartridge may have a plurality of fluid wells or reservoirs holding a plurality of reagents, and a sample viewing area to view a biological sample. The reagents may be applied sequentially to the sample by opening a specific valve formed in an elastomeric, flexible layer under the fluid well. The fluid channels may be formed in a first rigid plastic layer to conduct the reagent to the sample. Pneumatic channels for applying suction or pressure to the valves may be formed in a second rigid, plastic layer.

Multilevel disposable cartridge for biological specimens

The invention is directed to disposable cartridge for electroporation of cells, comprising a fluid compartment in an interior of the disposable cartridge; a first fluid port for providing cell suspension to the fluid compartment, and a second fluid port for delivering a fluid comprising at least one compound to be electroporated into the cells to the fluid compartment; a first electrode and a second electrode disposed in the fluid compartment; at least one exit port which delivers the fluid from the fluid compartment wherein the first and second fluid port have a fluid communication to a mixing channel which has a fluid communication to the fluid compartment, and a third ground electrode and a fourth ground electrode.

Disposable cartridge for electroporation

Automated method for sterile processing of cells by centrifugation and column chromatography

Preparing genetically modified cells using a device that is configured for sterile processing of cells at the bedside or in a surgical room

Preparing antigen-specific T cells using a self-enclosed processing system that contains both a centrifuge and a magnetic separation column

Self-contained disposable tubing set for sterile preparation of cells by culturing, centrifugation, and column chromatography

The invention is directed to a centrifuge chamber comprising a cylinder having a base plate and a cover plate, a rotational axis with at least one port for input and/or output of liquids, at least one port for input of gases and at least one layer for cell culturing, wherein the layer for cell culturing comprises a gas-permeable membrane on which cells can be cultured and wherein the at least one port for input and/or output of gases is connected to the gas-permeable membrane.

Centrifugation chamber with gas permeable membrane layers for cell cultivation

A cell strainer for separating particles from a cell suspension, having an upper portion with at least one filter area lying essentially perpendicular to the direction of flow of the suspension and a lower portion adapted to fit into the openings of at least two sample tubes with different sized openings. The lower portion has a first section with shoulders or flanges having the diameter of the opening of a first tube and a second section having an inner and outer wall serving as a receptacle for the neck of a second tube, where the diameter of the first section is larger than the diameter of the second section.

Stackable cell strainer

The invention relates to a centrifuge for separating a sample into at least two components, comprising a chamber for receiving a sample to be centrifuged. According to the invention, the centrifuge further comprises a means for controlling the progress of the sample separation is located at the chamber.

Centrifuge for separating a sample into at least two components

Growing community of inventors

Bonn, Germany

Eiad Kabaha