Tel Aviv University

Tel Hashomer Medical Research Infrastructure and Services Ltd.

Technology Innovation Momentum Fund (israel) Limited Partnership

Xidian University

Yeda Research and Develpment & Co. Ltd

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Technology Innovation Momentum Fund (isreal) Limited Partnership

Ehud Gazit

Ron Naaman

Meital Reches

Ludmila Buzhansky

Lihi Adler-Abramovich

Arie Orenstein

Genady Kostenich

Yoseph Salitra

Mor Oron-Herman

Talia Shekhter Zahavi

Zvi Nevo

Itai Benhar

Shmuel Einav

Nathan Nelson

Iftach Yacoby

Or Berger

Moran Aviv

Ulrich Abel

Michael Ioffe

Ronit Shaltiel-Karyo

Daniel Segal

Roni Scherzer

Tomer Cohen

Anat Frydman-Marom

Yaniv Amir

Alon Sayer

Gil Rosenman

Judith Rishpon

Shira Yochelis

Sigal Lazar

Kai Tao

Rusen Yang

Ludmilla Buzhansky

Johann Elbaz

Yu Chen

Sharon Gilead

Irena Grigoriants

Rina Sevostianov

Santu Bera

Sudipta Mondal

Vasantha Basavalingappa

Talia Shekhter Zehavi

Shai Zilberzwige-Tal

Izhack Cherny

Miri Yemini

Yair Porat

Daniel Aronov

Ohad Carny

Michael Ovadia

Yaron Bram

Pini Marco

Assaf Mahler

Rafael Ischakov

Mor Herman-Oron

Yossi Paltiel

Naama Goren

Amit Kumar Mondal

A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.

Piezoelectric peptide-based materials and piezoelectric devices containing same

Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic moieties being an end-capping modified aromatic dipeptide and at least another type of the aromatic moieties being an amine-modified halogenated aromatic amino acid, are provided. Also provided are processes of preparing the hybrid hydrogels and uses thereof.

Self-assembled hybrid hydrogels formed of a short aromatic peptide and an aromatic amino acid

Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Synthetic somatostatin receptor ligands

A formulation includes an active agent, a thickening/solidifying agent, and an antioxidant. The active agent is 9-cis-&#x3b2;-carotene (9CBC) or a derivative thereof of the following formula: where Ris H or methyl; X is optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.

Method for synthesis of 9-cis-beta-carotene and formulations thereof

The present invention provides cell-free systems comprising: (i) a transcription compartment; (ii) a barrier; and (iii) a translation compartment, methods for producing proteins and performing post-translational modifications thereon using such systems, and kits comprising such systems.

Programmable artificial cell

The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.

Formation of functionalized cancer targeting nanoparticles by supramolecular co-assembly

Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.

Peptide-based hydrogel particles and uses thereof

The present invention relates to a method for total chemical synthesis of 9-cis-&#x3b2;-carotene (9CBC), and further provides stable formulations thereof.

Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.

Self-assembled structures composed of monomers of peptide nucleic acid and tunable photonic crystals made therefrom

Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.

Self-assembled peptide nucleic acids

Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.

Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof

A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.

Formation of organic nanostructure array

Growing community of inventors

Ramat-Hasharon, Israel

Ehud Gazit