Arcus Biosciences, Inc.

Other

Ehesan Ul Sharif

Jay Patrick Powers

Manmohan Reddy Leleti

Dillon Harding Miles

Brandon Reid Rosen

Jaroslaw Kalisiak

Kenneth Victor Lawson

Erick Allen Lindsey

Eric Newcomb

Laurent Pierre Paul Debien

Rhiannon Thomas-Tran

Juan Carlos Jaen

Debashis Mandal

Jenna Leigh Jeffrey

Joel Worley Beatty

Laurent Debien

Laurent Pierre Debien

Compound that is an inhibitor of at least one of the Aand Aadenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine Areceptor and/or the adenosine Areceptor.

Azolopyrimidine for the treatment of cancer-related disorders

Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

Inhibitors of adenosine 5'-nucleotidase

Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5&#x2032;-nucleotidase, ecto is also provided.

Inhibitors of CD73-mediated immunosuppression

A compound that is an inhibitor of at least one of the Aand Aadenosine receptors having Formula (I) and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine Areceptor and/or the adenosine Areceptor.

Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders

Compounds of Formula I that inhibit at least one of the Aand Aadenosine receptors, and compositions containing compounds of Formula I and methods for synthesizing compounds of Formula I, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine Areceptor and/or the adenosine Areceptor.

Quinazoline-pyridine derivatives for the treatment of cancer-related disorders

Modulators of 5'-nucleotidase, ecto and the use thereof

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Menlo Park, CA, United States of America

Ehesan Ul Sharif