Arcus Biosciences, Inc.

Ehesan Ui Sharif

Jay Patrick Powers

Manmohan Reddy Leleti

Dillon Harding Miles

Juan Carlos Jaen

Jaroslaw Kalisiak

Kenneth Victor Lawson

Brandon Reid Rosen

Erick Allen Lindsey

Eric Newcomb

Xuelei Yan

Debashis Mandal

Laurent Pierre Paul Debien

Rhiannon Thomas-Tran

Joel Worley Beatty

Jenna Leigh Jeffrey

Guillaume Mata

Samuel Lawrie Drew

Artur Karenovich Mailyan

Jeremy Thomas Andre Fournier

Laurent Debien

Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

Modulators of 5'-nucleotidase, ecto and the use thereof

Compounds that inhibit PI3Kγ, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by PI3Kγ.

2,3,5-trisubstituted pyrazolo[1,5-A]pyrimidine compounds

Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5&#x2032;-nucleotidase, ecto is also provided.

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Menlo Park, CA, United States of America

Ehesan Ui Sharif