Boehringer Mannheim Gmbh

Egon Roesch

Max Thiel

Wolfgang Kampe

Kurt Stach

Wolfgang Bartsch

Gisbert Sponer

Ernst-Christian Witte

Karl Dietmann

Walter-Gunar Friebe

Wolfgang Schaumann

Klaus Strein

Fritz Wiedemann

Carl H Ross

Herbert Berger

Otto-Henning Wilhelms

Karlheinz Stegmeier

Androniki Roesch

Jens-Peter Holck

Hans P Wolff

Werner Winter

Alfred Mertens

Bernd Muller-Beckmann

Kurt Stach, Deceased

Helmut Michel

Franz Braun

Erich Fauland

Wolfgang Weckerle

Klaus Hardebeck

Harald Stork

By Werner Plattner, Administrator

Alfred Popelak

Ansgar Lerch

Hans P Wolfe

Alfred Martens

Bernd Muller-Beckman

Herman Hindermayr

The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula:  These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

Indoline compounds for synthesis of pharmaceutically active

The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.3 -C.sub.7 cycloalkyl;

Pyrrolobenzimidazoles, pharmaceutical compositions containing them and

Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl;

Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions

The present invention provides heteroaryloxypropanolamines and pharmaceutical compositions containing them, for combating, and for the prophylaxis of, cardiac and circulatory diseases. The heteroaryloxypropanolamines of the present invention are of the general formula: ##STR1## wherein A is a bi- or tricyclic heteroaromatic radical, which is optionally partly hydrogenated, X is a straight-chained or branched alkylene chain containing 2 to 6 carbon atoms, R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms or lower alkyl or benzyl radicals, R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms or lower alkyl, benzyl, formyl, lower alkanoyl, cyano, hydroxymethyl, lower alkoxycarbonyl or carbamoyl radicals or the divalent substituents sulfur or oxygen and R.sub.6, R.sub.7 and R.sub.8, which can be the same or different, are hydrogen or halogen atoms, lower alkyl, nitro, amino, lower alkylthio or lower alkoxy radicals or R.sub.6 and R.sub.7 together represent an optionally unsaturated trimethylene chain; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.

Indazoloxypropanolamine derivatives and use in combating, and for the

The invention provides sulphonamides of the formula ##STR1## wherein R is a hydrogen atom or a lower alkyl radical;

Sulphonamidophenylcarboxylic acid compounds and pharmaceutical

An aminopropanol compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from hydrogen and lower alkyl; or

Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering

New amine derivatives of 4-hydroxy-2,1,3-benzthiadiazoles of the formula: ##STR1## wherein R is straight-chained or branched alkyl and the pharmacologically compatible salts thereof, that are markedly effected as inhibitors of adrenogenic .beta.-receptors and thus useful for the treatment and prophylaxis of cardiac and circulatory diseases.

4-Hydroxy-2,1,3-benzthiadiazole compounds and .beta.-adrenergic method

The present invention provides benzopyranyl ethers of the general formula: ##STR1## wherein A is an alkylene radical containing 2 to 4 carbon atoms and R is a hydrogen atom or an acyl radical; as well as the salts thereof with pharmacologically acceptable acids. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for treating allergic diseases.

Benzopyran compounds, pharmaceutical compositions containing them and

2-benzimidazolinone compounds of the formula ##STR1## wherein R is lower alkyl,

2-Benzimidazolinone compounds and therapeutic compositions

Phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl

Phenoxyalkylcarboxylic acid compounds and thrombocyte-aggregation

Anti-allergy novel 1-oxo-1H-pyrimido[6,1-b]benzthiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently is hydrogen, halogen, hydroxy, nitro, trifluoromethyl, or lower alkyl, alkoxy or alkylthio, or

1-Oxo-1H-pyrimido[6,1-b]benzthiazole derivatives

New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,

Aminopropanol substituted indole compounds and compositions for the

Novel 4-hydroxy-2-benzimidazoline-thione compound of the formula: ##STR1## wherein R is lower alkyl;

4-Hydroxy-2-benzimidazoline-thione compounds and pharmaceutical

Novel phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein B is a valency bond or a straight-chained or branched, saturated or unsaturated hydrocarbon radical containing up to 3 carbon atoms;

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Mannheim, Germany

Egon Roesch